The Emerging Role of DNA Methylation in Kidney Transplantation: A Perspective

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
L HeylenB Sprangers

Abstract

Allograft outcome depends on a range of factors, including donor age, the allo-immune response, ischemia-reperfusion injury, and interstitial fibrosis of the allograft. Changes in the epigenome, and in DNA methylation in particular, have been implicated in each of these processes, in either the kidney or other organ systems. This review provides a primer for DNA methylation analyses and a discussion of the strengths and weaknesses of current studies, but it is also a perspective for future DNA methylation research in kidney transplantation. We present exciting prospects for leveraging DNA methylation analyses as a tool in kidney biology research, and as a diagnostic or prognostic marker for predicting allograft quality and success. Topics discussed include DNA methylation changes in aging and in response to hypoxia and oxidative stress upon ischemia-reperfusion injury. Moreover, emerging evidence suggests that DNA methylation contributes to organ fibrosis and that systemic DNA methylation alterations correlate with the rate of kidney function decline in patients with chronic kidney disease and end-stage renal failure. Monitoring or targeting the epigenome could therefore reveal novel therapeutic approaches in transplantation an...Continue Reading

References

Apr 3, 2003·Nature Reviews. Cancer·Peter W Laird
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert A MetzgerRobert M Merion
Jan 14, 2004·Kidney International·Abdulla K SalahudeenWarren May
May 22, 2004·Nature Reviews. Genetics·Melissa J Fazzari, John M Greally
Jun 3, 2005·Cancer Research·David R HodgeWilliam L Farrar
Dec 19, 2006·Transplantation Proceedings·J R PrattJ P A Lodge
Oct 26, 2007·American Journal of Physiology. Renal Physiology·Adebayo D AkintolaAlan R Parrish
Mar 29, 2008·Cancer Letters·Rodrigo FrancoMihalis I Panayiotidis
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Girdhari LalJonathan S Bromberg
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tibor A RauchGerd P Pfeifer
Jan 20, 2009·Nature Reviews. Immunology·Christopher B WilsonMasayuki Sekimata
Mar 25, 2009·Nature Reviews. Genetics·Howard Cedar, Yehudit Bergman
Jul 9, 2009·Human Molecular Genetics·Jenny A WatsonAmanda McCann
Jul 31, 2009·Blood·Girdhari Lal, Jonathan S Bromberg
Oct 6, 2009·Nature Genetics·Ann-Marie BröskeFrank Rosenbauer
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shuei-Liong LinJeremy S Duffield
Apr 27, 2010·Nature Medicine·Wibke BechtelMichael Zeisberg
Jun 18, 2010·Kidney International·Ryota KikuchiKunio Shiota
Aug 7, 2010·BMC Medical Genomics·Christopher G BellDavid A Savage
Oct 1, 2010·Kidney International·Rama S DwivediDominic S C Raj
Oct 15, 2010·Nature Biotechnology·Anna Portela, Manel Esteller
Dec 15, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Carmen SapienzaMichael Madaio
Feb 4, 2011·Journal of the American Society of Nephrology : JASN·Sik LeeLloyd G Cantley
May 28, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Nancy ChiaDouglas M Ruden
Jun 2, 2011·Genome Research·Aimée M DeatonAdrian Bird
Jul 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O BestardJ M Grinyó
May 26, 2012·Biochemical and Biophysical Research Communications·Ning HuangHao Wang
Sep 5, 2012·Nature Reviews. Genetics·Holger Heyn, Manel Esteller
Oct 23, 2012·Cellular Signalling·Er-Bao BianJun Li
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
Jan 8, 2013·Journal of the American Society of Nephrology : JASN·Insa M SchmidtLloyd G Cantley
Feb 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aras TokerJochen Huehn

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Citations

Jul 5, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I M ShapeyD van Dellen
Feb 9, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B Suarez-AlvarezC Lopez-Larrea
Dec 4, 2019·Immunopharmacology and Immunotoxicology·Nikoo Hossein-KhannazerMohammad Noorisepehr
May 28, 2020·Frontiers in Immunology·Rossana FranzinGiuseppe Castellano
Feb 26, 2019·Clinical Science·Jinhua Tang, Shougang Zhuang
Dec 15, 2020·Current Opinion in Organ Transplantation·Karin BoerCarla C Baan

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