The emerging role of fibroblast-like synoviocytes-mediated synovitis in osteoarthritis: An update.

Journal of Cellular and Molecular Medicine
Dafei HanWei Wei

Abstract

Osteoarthritis (OA), the most ubiquitous degenerative disease affecting the entire joint, is characterized by cartilage degradation and synovial inflammation. Although the pathogenesis of OA remains poorly understood, synovial inflammation is known to play an important role in OA development. However, studies on OA pathophysiology have focused more on cartilage degeneration and osteophytes, rather than on the inflamed and thickened synovium. Fibroblast-like synoviocytes (FLS) produce a series of pro-inflammatory regulators, such as inflammatory cytokines, nitric oxide (NO) and prostaglandin E2 (PGE2 ). These regulators are positively associated with the clinical symptoms of OA, such as inflammatory pain, joint swelling and disease development. A better understanding of the inflammatory immune response in OA-FLS could provide a novel approach to comprehensive treatment strategies for OA. Here, we have summarized recently published literatures referring to epigenetic modifications, activated signalling pathways and inflammation-associated factors that are involved in OA-FLS-mediated inflammation. In addition, the current related clinical trials and future perspectives were also summarized.

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Citations

Feb 6, 2021·International Journal of Molecular Sciences·Davor CaricKatarina Vukojevic
Jul 26, 2021·Arthritis Research & Therapy·Roxana CorasMonica Guma

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Methods Mentioned

BETA
nuclear translocation
histone acetylation
acetylation
acetylates
biopsies
imaging techniques

Clinical Trials Mentioned

NCT02709486
NCT02697773
NCT02528188
NCT03285646
NCT02095548
NCT02536833
NCT03122860
NCT03706521
NCT03928184
NCT02964624

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