The emerging role of histologic disease activity assessment in ulcerative colitis

Gastrointestinal Endoscopy
Rish K PaiGregory Y Lauwers

Abstract

Assessment of disease activity is essential for developing and determining appropriate therapy in patients with ulcerative colitis (UC). Validated clinical and endoscopic scoring systems have been established to accurately define disease activity. Clinical and endoscopic treatment targets have also been proposed, with gastroenterologists encouraged to optimize medical therapy to achieve these targets. Recently, histology has been recognized as an important prognostic factor and potential treatment target in patients with UC. This review summarizes the recent literature regarding histologic scoring indices in UC and offers practical guidance to gastroenterologists on how to interpret histologic data. Substantial evidence indicates that histology accurately predicts clinical relapse, hospitalization, corticosteroid use, and development of dysplasia. Furthermore, compared with endoscopy, findings suggest that histology may be more predictive of these outcomes. Because microscopic disease activity can persist in the absence of clinical or endoscopic disease activity, histology may be the ideal marker of inflammation. Standardized definitions of histologic response and remission and a biopsy procurement protocol are needed to guide ...Continue Reading

References

Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Nov 1, 1966·The American Journal of Digestive Diseases·R Wright, S R Truelove
Aug 26, 1998·The American Journal of Surgical Pathology·C G Kleer, H D Appelman
Jun 9, 1956·British Medical Journal·S C TRUELOVE, W C RICHARDS
Feb 6, 2004·Gastroenterology·Matthew RutterAlastair Forbes
Apr 24, 2008·Human Pathology·Alexandros D PolydoridesRhonda K Yantiss
Dec 9, 2010·Alimentary Pharmacology & Therapeutics·W KruisUNKNOWN International Salofalk OD Study Group
Jan 5, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sandro ArdizzoneGabriele Bianchi Porro
May 7, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Sheenam AzadAjit Sood
Nov 10, 2011·Inflammatory Bowel Diseases·Judith E BaarsChristien J van der Woude
Nov 14, 2012·The American Journal of Gastroenterology·Talat BessissowGert De Hertogh
Mar 23, 2013·Inflammatory Bowel Diseases·Bart LemmensGert De Hertogh
Apr 18, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laura RosenbergAlan C Moss
Oct 11, 2013·Inflammatory Bowel Diseases·Sebastian WolffWolfgang Kruis
May 8, 2014·World Journal of Gastroenterology : WJG·Burton I KorelitzGeorgia Panagopoulos
May 9, 2014·Current Opinion in Gastroenterology·Alan C Moss
Jul 1, 2014·Gastrointestinal Endoscopy Clinics of North America·Alissa WalshSimon Travis
Jul 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jordi GuardiolaFrancisco Rodríguez-Moranta
Jul 22, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P ZezosN Evgenidis
Nov 2, 2014·Gut·Mahmoud H MosliBarrett G Levesque
Aug 26, 2015·The American Journal of Gastroenterology·L Peyrin-BirouletJ-F Colombel
Oct 16, 2015·Gut·Aude Marchal-BressenotLaurent Peyrin-Biroulet
Oct 18, 2015·Gut·Mahmoud H MosliBarrett G Levesque
Jan 14, 2016·Current Gastroenterology Reports·Britt Christensen, David T Rubin
Feb 27, 2016·Inflammatory Bowel Diseases·Klaus TheedeAnette Mertz Nielsen
Mar 17, 2016·Digestive Diseases·Marietta Iacucci, Subrata Ghosh
May 6, 2016·The New England Journal of Medicine·William J SandbornUNKNOWN TOUCHSTONE Study Group
Aug 28, 2016·Gut·Aude Marchal-BressenotLaurent Peyrin-Biroulet
Dec 3, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sara MorgensternAmit Assa
Feb 28, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Britt ChristensenDavid T Rubin
May 4, 2017·The New England Journal of Medicine·William J SandbornUNKNOWN OCTAVE Induction 1, OCTAVE Induction 2, and OCTAVE Sustain Investigators
Aug 28, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Christopher MaVipul Jairath
Sep 30, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Margalida CalafatEugeni Domènech

❮ Previous
Next ❯

Citations

Mar 7, 2019·The American Journal of Gastroenterology·David T RubinMillie D Long
Apr 26, 2019·The American Journal of Gastroenterology·Millie D Long, David T Rubin
Sep 6, 2019·Current Gastroenterology Reports·Christopher M JohnsonThemistocles Dassopoulos
Dec 29, 2019·Inflammatory Bowel Diseases·David KevansMark S Silverberg
Dec 26, 2019·Expert Opinion on Biological Therapy·Tarun Chhibba, Christopher Ma
Jan 17, 2020·Alimentary Pharmacology & Therapeutics·Rish K PaiBrian G Feagan
Jan 23, 2020·Journal of Crohn's & Colitis·Fernando MagroUNKNOWN Portuguese IBD Study Group [GEDII]
Jun 7, 2020·Journal of Crohn's & Colitis·Fernando MagroRoger Feakins
Dec 28, 2019·Journal of Crohn's & Colitis·Marc Ferrante, João Sabino
Jun 10, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Jimil ShahRakesh Kochhar
Aug 15, 2019·Inflammatory Bowel Diseases·Sumona Bhattacharya, Raymond K Cross
Oct 7, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kentaro MoriichiToshikatsu Okumura
Dec 19, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Reena KhannaBrian G Feagan
Jan 21, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yamei HuangChangming Li
Oct 30, 2020·Clinical Epidemiology·Jordan E AxelradUNKNOWN SWIBREG Study Group
Mar 9, 2021·PloS One·Christian Børde ArktegRasmus Goll
May 22, 2021·Alimentary Pharmacology & Therapeutics·Laerke Müller OlsenAnne-Marie Kanstrup Fiehn
Sep 30, 2021·The New England Journal of Medicine·William J SandbornUNKNOWN True North Study Group
Dec 30, 2021·Journal of Biochemical and Molecular Toxicology·Shivani SinglaGopabandhu Jena
Aug 3, 2021·European Journal of Gastroenterology & Hepatology·Irene González-PartidaYago González-Lama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
L Peyrin-BirouletWendy Kampman
© 2022 Meta ULC. All rights reserved