The emerging role of human TBK1 in virus-induced autophagy

Autophagy
Ahmad Liyana, Sancho-Shimizu Vanessa

Abstract

Recent studies have suggested a role for TBK1 in mediating inflammation through macroautophagy/autophagy. While its function in inducing interferon production in response to viral infection has been extensively studied, its role in antiviral autophagy is only beginning to be appreciated. Herein we discuss the role of this multifunctional protein in both antiviral IFN production and in cytoprotective autophagy during HSV-1 infection. Lastly, we highlight the potential implication of TBK1 in the management of inflammation through autophagy, particularly within the central nervous system.

References

Oct 9, 2018·The Journal of Allergy and Clinical Immunology·Liyana AhmadVanessa Sancho-Shimizu

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Citations

Dec 31, 2020·Viruses·Christos DogrammatzisMaria Kalamvoki
Nov 17, 2020·Frontiers in Immunology·Peng Zhao, Alan R Saltiel
Dec 18, 2021·Expert Reviews in Molecular Medicine·Yixin LiuXiaotao Jiang

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