The emerging role of immunothrombosis in paediatric conditions

Pediatric Research
Thomas FranchiStefano Giuliani

Abstract

Immunothrombosis is a physiological process based on the release of neutrophil extracellular traps (NETs) to immobilise, contain and kill bacteria. This is an innate immune response in which the local activation of blood coagulation exerts the critical protective function during microbial infection. In recent years, there has been much interest in the adult literature about the key role of immunothrombosis in pathologic states including thrombosis, cancer, sepsis and trauma. Currently, little research has been done into its role in paediatric conditions. We conducted a literature search of the National Library of Medicine (MEDLINE/PubMed) from the years 2000 to May 2018 and qualitatively identified 24 relevant papers. References of articles included for full-text review were checked for relevant publications. Our aim is to summarise the most relevant evidences regarding an excessive production or defective removal of NETs in paediatric conditions. In particular, we have divided the role of immunothrombosis into acute (sepsis, necrotising enterocolitis, otitis media, neonatal arterial ischaemic stroke, haemolytic anaemic diseases) and chronic (systemic lupus erythematous, type 1 diabetes mellitus, respiratory diseases, graft-ver...Continue Reading

References

Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
Mar 10, 2005·Vaccine·Allan W CrippsJennelle M Kyd
Feb 21, 2006·Current Biology : CB·Katharina BeiterBirgitta Henriques-Normark
Jun 21, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Rocío ParodyUNKNOWN Infectious/Non-infectious Complications Subcommittee of the Grupo Español de Trasplante Hematopoyético (GETH)
Sep 19, 2006·Immunity·Jacques Banchereau, Virginia Pascual
Jan 8, 2008·Lancet·M D Cappellini, G Fiorelli
May 19, 2009·Nature Medicine·Kai KessenbrockDieter E Jenne
Mar 31, 2010·Leukemia & Lymphoma·Charulata RamaprasadDavid L Pitrak
Jul 7, 2010·Microbes and Infection·Allison McCormickFrank Ebel
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tobias A FuchsDenisa D Wagner
Oct 20, 2010·Infection and Immunity·Richard A JuneauW Edward Swords
Nov 16, 2010·Cell Host & Microbe·Ohn A ChowVictor Nizet
May 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eneida VillanuevaMariana J Kaplan
Sep 10, 2011·EMBO Molecular Medicine·Xavier Bosch
Dec 16, 2011·Journal of Neuroimmunology·Matthias NaegeleMireia Sospedra
Feb 22, 2012·American Journal of Respiratory Cell and Molecular Biology·Alice V DuboisSylvie Attucci
Jun 12, 2012·The Journal of Clinical Investigation·Axelle CaudrillierMark R Looney
Jul 28, 2012·Critical Care : the Official Journal of the Critical Care Forum·Wei MengTim T Lögters
Sep 8, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariana J Kaplan, Marko Radic
Dec 12, 2012·Nature Reviews. Immunology·Bernd Engelmann, Steffen Massberg
Jan 26, 2013·Diabetes·Andrea ValleManuela Battaglia
Jun 5, 2013·Seminars in Immunopathology·Nora Branzk, Venizelos Papayannopoulos
Jul 3, 2013·FEMS Microbiology Letters·Jeroen D Langereis, Peter W M Hermans
Sep 28, 2013·Current Diabetes Reports·Jaakko Tuomilehto
Oct 10, 2013·Stroke; a Journal of Cerebral Circulation·Adam Kirton, Gabrielle Deveber
Mar 4, 2014·Archives of Disease in Childhood·A MidgleyM W Beresford
Jun 27, 2014·Thrombosis and Haemostasis·Sacha F de StoppelaarTom van der Poll
Sep 16, 2014·Critical Care : the Official Journal of the Critical Care Forum·Toshiaki IbaHidesaku Asakura
Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rahul MittalXue Zhong Liu
Apr 10, 2015·Canadian Journal of Gastroenterology & Hepatology·Bashaar AlibrahimBaljinder Salh
Jul 7, 2015·Current Opinion in Rheumatology·Anna Huttenlocher, Judith A Smith

❮ Previous
Next ❯

Citations

Aug 29, 2019·Frontiers in Pediatrics·Carlo PietrasantaOfer Levy
Nov 22, 2019·Frontiers in Immunology·Nonantzin Beristain-CovarrubiasAdam F Cunningham
Jan 26, 2021·Frontiers in Pediatrics·Michaela KlinkeMichael Boettcher
Jan 26, 2021·Frontiers in Pediatrics·Alison B Nair, Robert I Parker
Jun 24, 2021·Arquivos brasileiros de cardiologia·Maria de Fátima Rodrigues DinizGabriela Nunes Leal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Journal of Thrombosis and Haemostasis : JTH
T J GouldP C Liaw
South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
M R Davies
© 2022 Meta ULC. All rights reserved