Abstract
Adoptive T cell therapy is a form of cellular therapy that utilizes human immune cells, often empowered by the expression of recombinant proteins, to attack selected targets present on tumor or infected cells. T cell-based immunotherapy has been progressing over the past several decades, and reached a milestone with the recent US Food and Drug Administration (FDA) approval of chimeric antigen receptor T cell therapy for relapsed and refractory leukemia and lymphoma. Although most studies have used viral vectors, a growing number of researchers have come to appreciate in vitro-transcribed (IVT) mRNA for the development, testing, and application of T cell-based immunotherapeutics. IVT mRNA offers inherent safety features, highly efficient recombinant protein translation, and the ability to control pharmacokinetic properties of the therapy. In this review, we discuss the history of IVT mRNA in adoptive T cell therapy, from tumor-infiltrating lymphocytes and T cell receptor-based therapies to chimeric antigen receptor therapy and gene-editing techniques, as well as prior and ongoing clinical trials.
Citations
Jul 7, 2019·Current Hematologic Malignancy Reports·Steven L Highfill, David F Stroncek
Feb 26, 2020·Nanomaterials·Itziar Gómez-AguadoAna Del Pozo-Rodríguez
Mar 4, 2020·Expert Opinion on Biological Therapy·Sneha RamakrishnaCrystal Mackall
May 22, 2019·Cells·Stefan StoiberSebastian Kobold
Aug 9, 2020·Cancers·Thomas J GardnerDavid Scheinberg
Jul 8, 2020·Leukemia·Liang LinYu-Tzu Tai
Dec 20, 2019·Journal of Hematology & Oncology·Qinghua HeJinsheng Weng
Jul 9, 2020·Science Advances·Jennifer NelsonJohn L Joyal
Nov 29, 2020·Nature Communications·N N ParayathM T Stephan
Jan 22, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Somnath MukherjeeDavid Stroncek
Nov 17, 2020·Frontiers in Chemistry·Maria L GuevaraStefano Persano
Nov 8, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bastien DuckertMaarten Fauvart
Feb 23, 2020·Antiviral Research·Anthony T Tan, Sophia Schreiber
Mar 5, 2021·Molecular Cancer·Lien Van HoeckeSandra Van Lint
Aug 30, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rui ZhangLi Yang
May 2, 2021·Biotechnology Advances·Laurens RaesKevin Braeckmans
Jul 3, 2021·Comptes rendus biologies·Félix Rey
Jun 18, 2021·Nano-micro Letters·Laurens RaesKevin Braeckmans
Jan 18, 2020·Nano Letters·Margaret M BillingsleyMichael J Mitchell
Aug 8, 2020·Immunity·Wentao LiHaopeng Wang
Aug 16, 2021·Blood Cancer Journal·Alejandra LeivasJoaquín Martínez-López
Jun 24, 2021·Molecular Cancer Therapeutics·Wen-Hsin Sandy LeeCheng-I Wang
Jun 7, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·István TombáczHamideh Parhiz
Oct 21, 2021·Nano Letters·Margaret M BillingsleyMichael J Mitchell
Jan 12, 2022·Current Opinion in Hematology·Jan KoedamGerhard Ehninger
Dec 17, 2021·Cancer Immunology Research·Ti WenHaidong Dong