The Emerging Role of Innate Immunity in Chronic Kidney Diseases.

International Journal of Molecular Sciences
Philip Chiu-Tsun TangPatrick Ming-Kuen Tang

Abstract

Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue fibrosis that finally results in an irreversible end-stage renal disease (ESRD). Renal inflammation recruits and activates immunocytes, which largely promotes tissue scarring of the diseased kidney. Importantly, studies have suggested a crucial role of innate immunity in the pathologic basis of kidney diseases. This review provides an update of both clinical and experimental information, focused on how innate immune signaling contributes to renal fibrogenesis. A better understanding of the underlying mechanisms may uncover a novel therapeutic strategy for ESRD.

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Citations

Feb 9, 2021·Frontiers in Medicine·Elisavet StavropoulouEugenia Bezirtzoglou
Apr 6, 2021·Frontiers in Medicine·Elisavet StavropoulouEugenia Bezirtzoglou
Apr 29, 2021·Journal of Inflammation Research·Ting-Ting ChenWu-Yi Sun
May 25, 2021·Frontiers in Physiology·Bao-Yi ShaoHai-Yong Chen
May 26, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mi-Gyeong GwonKwan-Kyu Park
Jun 10, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Megan VierhoutKjetil Ask
Jun 15, 2021·Frontiers in Medicine·Alex Siu Wing ChanPatrick Ming Kuen Tang
Jul 25, 2021·International Journal of Molecular Sciences·Jeff Yat-Fai ChungPatrick Ming-Kuen Tang

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BETA
nuclear translocation
single-cell sequencing

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