The emerging role of innate immunity in protection against HIV-1 infection

Vaccine
Thomas LehnerKaboutar Babaahmady

Abstract

Preventive immunization against HIV-1 infection requires a rapid immune response that does not rely exclusively on B or T cell memory. Innate immunity may fulfill this function as it may be activated directly at the time of HIV-1 transmission, inhibit early HIV-1 replication, stimulate adaptive immunity and enable specific antibodies followed by CD8(+) T cells to deal with the virus effectively. The three components of innate immunity - cellular, extracellular and intracellular - are presented, with an example given for each of these components; gammadelta T cells, CC chemokines and APOBEC3G. This brief account is presented to highlight the immuno-virological concept of coordinating activated innate immunity with adaptive antibody and T cell responses in preventive vaccination against HIV-1 infection.

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Citations

Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Juliane HaedickeMojgan H Naghavi
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Jul 2, 2011·Veterinary Immunology and Immunopathology·Ana DoménechEsperanza Gomez-Lucia

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