The emerging role of microRNAs in Alzheimer's disease

Frontiers in Physiology
Grazia D FemminellaGiuseppe Rengo

Abstract

MicroRNAs (miRNAs) are small non-coding RNA which have been shown to regulate gene expression. The alteration ofmiRNAs expression has been associated with several pathological processes, including neurodegeneration. In the search for easily accessible and non-invasive biomarkers for Alzheimer's disease (AD) diagnosis and prognosis, circulating miRNAs are among the most promising candidates. Some of them have been consistently identified as AD-specific miRNAs and their targets also seem implicated in pathophysiological processes underlying AD. Here, we review the emerging role for miRNA in AD, giving an overview on general miRNAs biology, their implications in AD pathophysiology and their potential role as future biomarkers.

References

Apr 3, 2007·Neuroscience Letters·Claudie HooperRichard Killick
Apr 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sébastien S HébertBart De Strooper
Apr 24, 2010·Journal of Alzheimer's Disease : JAD·Peter T Nelson, Wang-Xia Wang
Jul 2, 2011·Journal of Molecular Neuroscience : MN·Nicole SchonrockJürgen Götz
Sep 29, 2011·The EMBO Journal·Athanasios ZovoilisAndre Fischer
Nov 29, 2011·Experimental Neurology·Nicole SchonrockJürgen Götz
Dec 14, 2011·Experimental Neurology·Hirosha GeekiyanageChristina Chan
Jan 21, 2012·Trends in Cell Biology·Xi ChenChen-Yu Zhang
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Feb 4, 2012·Molecular Neurobiology·Walter J Lukiw, Peter N Alexandrov
Jun 5, 2012·Neuroreport·Walter J LukiwSurjyadipta Bhattacharjee
Dec 5, 2012·Journal of Alzheimer's Disease : JAD·Grazia Daniela FemminellaDario Leosco
Sep 7, 2013·Frontiers in Molecular Neuroscience·Véronique DorvalSébastien S Hébert
Oct 18, 2013·Frontiers in Cellular Neuroscience·Emily F GoodallPamela J Shaw
Nov 19, 2013·Neurobiology of Aging·Daniel L Van den HoveBart P F Rutten
Nov 20, 2013·Biogerontology·Lloyd A Demetrius, Jane Driver
Dec 24, 2013·Neuron·Clifford R Jack, David M Holtzman
Jan 7, 2014·Frontiers in Cellular Neuroscience·Simona MaciottaYvan Torrente
Feb 5, 2014·Nature Reviews. Clinical Oncology·Heidi SchwarzenbachKlaus Pantel
Feb 18, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Grazia D Femminella, Paul Edison
Apr 1, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Pia B DanborgNiels H H Heegaard
Jun 6, 2014·Journal of Alzheimer's Disease : JAD·Grazia Daniela FemminellaNicola Ferrara
Sep 23, 2014·Neurobiology of Disease·Kelly T DineleyLarry Denner

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Citations

Feb 6, 2016·International Journal of Molecular Sciences·Bhairavi SrinageshwarJulien Rossignol
Feb 24, 2016·Frontiers in Aging Neuroscience·Paola PiscopoAnnamaria Confaloni
Dec 24, 2015·International Journal of Molecular Sciences·Yuhai ZhaoWalter J Lukiw
Mar 5, 2016·Frontiers in Neuroscience·Yuhai ZhaoWalter J Lukiw
Oct 7, 2015·Neurochemical Research·James M Hill, Walter J Lukiw
Dec 5, 2015·Journal of Applied Genetics·Anna Y Tang
Sep 16, 2016·Frontiers in Genetics·Elena MogilyanskyIsidore Rigoutsos
Sep 7, 2016·International Journal of Molecular Sciences·Nan ZhangJunfa Li
Jan 27, 2017·Biomarkers in Medicine·Vijitha ViswambharanAyyappan Anitha
Mar 11, 2017·Pharmacology & Therapeutics·Iyan Younus, Doodipala Samba Reddy
Sep 16, 2016·Molecular Neurobiology·Marta Cosín-TomásPerla Kaliman
Apr 18, 2018·Journal of Alzheimer's Disease : JAD·Jonas Mengel-FromNiels H H Heegaard
Sep 21, 2017·Scandinavian Journal of Immunology·M WalczykM Olesinska
Dec 5, 2017·Journal of Alzheimer's Disease : JAD·Paulami ChatterjeeNitin Rathi
Aug 30, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Durgesh TiwariChristina Gross
Jun 14, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A S VieiraI Lopes-Cendes
Jun 3, 2015·Journal of Cellular Physiology·Jin WangSubrata Sen
Dec 18, 2018·Journal of Cellular Biochemistry·Jing LiQiuling Tong
Dec 7, 2018·Journal of Alzheimer's Disease : JAD·Hasan A M M AlmansoubDan Liu
Apr 24, 2019·Aging and Disease·Saumyendra N SarkarJames W Simpkins
Sep 1, 2017·Nature Reviews. Neuroscience·Evgenia Salta, Bart De Strooper
Oct 21, 2015·Journal of Alzheimer's Disease : JAD·Helen Zong Ying WuKaren Mather
Jan 13, 2018·Wiley Interdisciplinary Reviews. RNA·M Laura IddaMyriam Gorospe
Sep 29, 2019·Journal of Alzheimer's Disease : JAD·Alexandre Amlie-WolfGerard D Schellenberg
Jan 9, 2020·In Vitro Cellular & Developmental Biology. Animal·Xiao ChengYongliang Zhang
Apr 18, 2020·American Journal of Alzheimer's Disease and Other Dementias·Vinicius Carolino SouzaOtávio Toledo Nóbrega
Dec 7, 2017·Oncotarget·Guohua GongChengxi Wei
Jan 27, 2018·Oncotarget·Fengmao AnChengxi Wei
Sep 8, 2016·Infection and Immunity·Steven C Y ChenPanos N Papapanou
Sep 17, 2016·Journal of Neuroinflammation·Pejman Rahimian, Johnny J He

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Methods Mentioned

BETA
PCR
transgenic

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