The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

International Immunopharmacology
Rasoul MirzaeiSajad Karampoor

Abstract

The novel coronavirus disease 2019 (COVID-19) pandemic has imposed significant public health problems for the human populations worldwide after the 1918 influenza A virus (IVA) (H1N1) pandemic. Although numerous efforts have been made to unravel the mechanisms underlying the coronavirus, a notable gap remains in our perception of the COVID-19 pathogenesis. The innate and adaptive immune systems have a pivotal role in the fate of viral infections, such as COVID-19 pandemic. MicroRNAs (miRNAs) are known as short noncoding RNA molecules and appear as indispensable governors of almost any cellular means. Several lines of evidence demonstrate that miRNAs participate in essential mechanisms of cell biology, regulation of the immune system, and the onset and progression of numerous types of disorders. The immune responses to viral respiratory infections (VRIs), including influenza virus (IV), respiratory syncytial virus (RSV), and rhinovirus (RV), are correlated with the ectopic expression of miRNAs. Alterations of the miRNA expression in epithelial cells may contribute to the pathogenesis of chronic and acute airway infections. Hence, analyzing the role of these types of nucleotides in antiviral immune responses and the characterizat...Continue Reading

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Citations

May 2, 2021·International Immunopharmacology·Sajad KarampoorHossein Keyvani
Jun 3, 2021·International Journal of Molecular Sciences·Noha Mousaad ElemamNabil Sulaiman
Jul 6, 2021·Journal of Neuroimmunology·Rasoul MirzaeiSajad Karampoor
Jul 13, 2021·Frontiers in Microbiology·Asuka NanboZhen Lin
Aug 28, 2021·International Journal of Molecular Sciences·Maria Narożna, Błażej Rubiś
Aug 28, 2021·Immunity, Inflammation and Disease·Sima KazemiMohammad Yousef Alikhani

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Methods Mentioned

BETA
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antagomir

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