The emerging role of NPNT in tissue injury repair and bone homeostasis

Journal of Cellular Physiology
Youqiang SunJiake Xu

Abstract

Nephronectin (NPNT), a highly conserved extracellular matrix protein, plays an important role in regulating cell adhesion, differentiation, spreading, and survival. NPNT protein belongs to the epidermal growth factor (EGF)-like superfamily and exhibits several common structural determinants; including EGF-like repeat domains, MAM domain (Meprin, A5 Protein, and Receptor Protein-Tyrosine Phosphatase µ), RGD motif (Arg-Gly-Asp) and a coiled-coil domain. It regulates integrins-mediated signaling pathways via the interaction of its RGD motif with integrin α8β1. Recent studies revealed that NPNT is involved in kidney development, renal injury repair, atrioventricular canal differentiation, pulmonary function, and muscle cell niche maintenance. Moreover, NPNT regulates osteoblast differentiation and mineralization, as well as osteogenic angiogenesis. Altered expression of NPNT has been linked with the progression of certain types of cancers, such as spontaneous breast tumor metastasis and malignant melanoma. Interestingly, NPNT gene expression can be regulated by a range of external factors such as tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), oncostatin M (OSM), bone morphogenic protein 2 (BMP2), Wnt3...Continue Reading

References

Jan 1, 1987·Annual Review of Cell Biology·C A Buck, A F Horwitz
Aug 1, 1995·The International Journal of Biochemistry & Cell Biology·C M Kielty, C A Shuttleworth
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Jul 27, 2001·The Journal of Cell Biology·J H Miner
Sep 8, 2001·The Journal of Biological Chemistry·N MorimuraK Tezuka Ki
Oct 21, 2004·Biochemical Society Transactions·M J HumphriesA P Mould
Nov 27, 2004·Trends in Cell Biology·Charles ffrench-Constant, Holly Colognato
Nov 6, 2007·FEBS Letters·Agasa MiyazonoRyutaro Kamijo
Nov 7, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chao-Wen ChengAnn Chen
Jan 25, 2008·BMC Bioinformatics·Yang Zhang
Feb 15, 2008·Cancer Science·Silke KuphalAnja K Bosserhoff
Oct 27, 2009·Developmental Biology·Tania Rozario, Douglas W DeSimone
Feb 15, 2011·Developmental Cell·Kazunori SunadomeEisuke Nishida
Feb 22, 2011·Cell·Hironobu FujiwaraFiona M Watt
Jun 11, 2011·American Journal of Respiratory Cell and Molecular Biology·Peter J CastaldiUNKNOWN COPDGene and Eclipse Investigators
Jun 22, 2011·Biochemical and Biophysical Research Communications·Masayuki TsukasakiRyutaro Kamijo
Dec 17, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shinya NakataniHideki Wanibuchi
Feb 14, 2012·Seminars in Cell & Developmental Biology·Chandramouli R ChillakuriPenny A Handford
Jul 31, 2012·Biochemical and Biophysical Research Communications·Masayuki TsukasakiRyutaro Kamijo
Dec 5, 2012·Biochemical and Biophysical Research Communications·Fuyuki F InagakiAtsushi Miyajima
Jan 30, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Yuya SatoKiyotoshi Sekiguchi
Oct 17, 2014·Thrombosis and Haemostasis·C PatraF B Engel
Nov 22, 2014·Current Opinion in Nephrology and Hypertension·Kianoush Kashani, John A Kellum
Dec 31, 2014·Nature Methods·Jianyi YangYang Zhang
Aug 20, 2015·Endocrine-related Cancer·Tobias ÅkerströmPer Hellman

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Citations

Feb 16, 2019·Current Stem Cell Research & Therapy·Lingbo KongDingjun Hao
Nov 2, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rive SarfsteinHaim Werner
Mar 7, 2021·Cancers·Synnøve Norvoll MagnussenGunbjørg Svineng

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