The emerging role of oncolytic virus therapy against cancer

Chinese Clinical Oncology
Luke Russell, Kah-Whye Peng

Abstract

This review discusses current clinical advancements in oncolytic viral therapy, with a focus on the viral platforms approved for clinical use and highlights the benefits each platform provides. Three oncolytic viruses (OVs), an echovirus, an adenovirus, and a herpes simplex-1 virus, have passed governmental regulatory approval in Latvia, China, and the USA and EU. Numerous other recombinant viruses from diverse families are in clinical testing in cancer patients and we highlight the design features of selected examples, including adenovirus, herpes simplex virus, measles virus, retrovirus, reovirus, vaccinia virus, vesicular stomatitis virus. Lastly, we provide thoughts on the path forward for this rapidly expanding field especially in combination with immune modulating drugs.

Citations

Mar 23, 2019·Thoracic Cancer·Yang BaiXing Su
Oct 31, 2019·Microbiology and Immunology·Maria TerrívelAna Miguel Matos
Jun 13, 2020·Cancers·Praveensingh B HajeriMasato Yamamoto
Jun 20, 2020·Human Gene Therapy·Lea KrutzkeStefan Kochanek
Nov 9, 2018·Frontiers in Immunology·Sonia Guedan, Ramon Alemany
Mar 13, 2020·Molekuliarnaia biologiia·G V KochnevaS V Kulemzin
Aug 25, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Noga LipschitzRavi N Samy
May 7, 2020·Frontiers in Oncology·Lizhi LiJian Ma
Jul 1, 2020·Cancers·Paulina Niedźwiedzka-RystwejJacek Roliński
Dec 23, 2020·Human Gene Therapy·Kyle McGrath, Gianpietro Dotti
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ke-Tao JinShi-Bing Wang
Dec 4, 2020·Journal for Immunotherapy of Cancer·Siwen Hu-LieskovanHolden T Maecker
Feb 12, 2020·European Journal of Pharmacology·Agata HadryśJoanna Jazowiecka-Rakus
Mar 7, 2021·International Journal of Molecular Sciences·Jinsha LiuSepideh Afshar
Mar 12, 2021·Current Oncology·Vanessa InnaoAlessandro Allegra
Mar 30, 2021·Biologics : Targets & Therapy·Tafere Mulaw Belete
Apr 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen YangXiangmin Tong
May 14, 2021·Virology Journal·Amir Sasan Mozaffari NejadAmir Ghaemi
Jun 3, 2021·Viruses·Nathália Alves Araújo de AlmeidaVanessa Salete de Paula
Jun 14, 2021·Human Immunology·Mohammad Hossein KazemiMohsen Hamidpour
Jun 19, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yu-Ting KuoLiang-Tzung Lin
Jul 3, 2021·Vaccines·Meshaal KhanShikha Jain
Aug 2, 2021·Cancer Cell International·Gang ChengShibing Wang
Sep 28, 2021·Journal of Medical Internet Research·Dominik WawrzutaMariusz Panczyk
Dec 2, 2021·Journal of the National Cancer Institute·Daniel DiMaioAmy Justice

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Review of Neurobiology
Jennifer C C Hu, Robert S Coffin
Liver International : Official Journal of the International Association for the Study of the Liver
Rafaela ArgnaniRuben Hernandez-Alcoceba
© 2022 Meta ULC. All rights reserved