The emerging role of substance P/neurokinin-1 receptor signaling pathways in growth and development of tumor cells.

Journal of Physiology and Biochemistry
Hossein JavidSeyed Isaac Hashemy

Abstract

Tachykinins (TKs) include an evolutionarily conserved group of small bio-active peptides which possess a common carboxyl-terminal sequence, Phe-X-Gly-Leu-Met-NH2. TKs also have been shown to have implications in different steps of carcinogenesis, such as angiogenesis, mitogenesis, metastasis, and other growth-related events. The biological actions of substance P (SP), as the most important member of the TK family, are mainly mediated through a G protein-coupled receptor named neurokinin-1 receptor (NK1R). More recently, it has become clear that SP/NK1R system is involved in the initiation and activation of signaling pathways involved in cancer development and progression. Therefore, SP may contribute to triggering a variety of effector mechanisms including protein synthesis and a number of transcription factors that modulate the expression of genes involved in these processes. The overwhelming insights into the blockage of NK1R using specific antagonists could suggest a therapeutic approach in cancer therapy. In this review, we focus on evidence supporting an association between the signaling pathways of the SP/NK1R system and cancer cell proliferation and development.

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Citations

Apr 3, 2020·Journal of Cellular Physiology·Nirvana Kalantari KhandaniSeyed Isaac Hashemy
Apr 24, 2020·Cranio : the Journal of Craniomandibular Practice·Dwight Jennings
Apr 12, 2020·Molecular Biology Reports·Shima LorestaniSeyed Isaac Hashemy
May 11, 2020·Cancer Metastasis Reviews·Ludger Johannes, Anne Billet
Oct 21, 2020·Cell Communication and Signaling : CCS·Alice LerouxJoëlle Amédée
Oct 2, 2020·Cancers·Fabian Bernhard Pallasch, Udo Schumacher
Nov 18, 2020·Trends in Pharmacological Sciences·Abigail C Cornwell, Michael E Feigin
May 13, 2021·Biochemistry Research International·Faranak KorfiSeyed Isaac Hashemy
Jul 24, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shahin AghamiriMojgan Bandehpour
Jul 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guihua DingQingbin Meng
Jul 9, 2021·Journal of Medicinal Chemistry·Rocío RecioInmaculada Fernández
Sep 28, 2021·Frontiers in Pharmacology·Weixia Zhong, Nissar A Darmani

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