The emerging role of the TGFβ tumor suppressor pathway in pancreatic cancer

Cell Cycle
David J BirnbaumDaniel Birnbaum

Abstract

Pancreatic adenocarcinoma is one of the most aggressive human cancers. It displays many different chromosomal abnormalities and mutations. To design new therapeutic strategies, it is important to identify the signaling pathways and gene networks within this apparent complexity that are predominantly altered. The TGFβ signaling pathway and associated transcription network emerges as a central actor of pancreatic oncogenesis. Its tumor suppressor function in this tissue can be affected by several alterations.

Citations

Jul 25, 2013·Cancer Letters·Rozita RoshaniThorsten Hagemann
Nov 29, 2014·Biochimica Et Biophysica Acta·Jia-Hao JiangXian-Jun Yu

Related Concepts

ARID1A protein, human
GATA6 protein, human
Nucleolar Proteins
Malignant Neoplasm of Pancreas
Transcription Factor
Signal Transduction
Transforming Growth Factor beta
GATA6 Transcription Factor
Malignant Neoplasms
Congenital Chromosomal Disease

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