The emerging role of transport systems in liver function tests

European Journal of Pharmacology
Bruno StiegerThomas M van Gulik

Abstract

Liver function tests are of critical importance for the management of patients with severe or terminal liver disease. They are also used as prognostic tools for planning liver resections. In recent years many transport systems have been identified that also transport substances employed in liver function tests. Such substances include endogenous bilirubin or exogenously administered indocyanine green, agents for magnetic resonance imaging, agents for single photon emission computed tomography or agents for breath tests. The increasing functional and molecular information on the respective transport systems should improve the management and as a result the outcome of patients scheduled for liver surgery or transplantation. To achieve the latter goal, clinical studies that assess individual patients' liver function over the course of their disease with liver function tests are needed to firmly establish and validate recently introduced and novel liver function markers.

References

Aug 1, 1977·Diabetologia·W HeptnerJ P Felber
Mar 15, 1975·Experientia·G Paumgartner, J Reichen
Jun 5, 1975·The New England Journal of Medicine·N F LaRussoM G Korman
Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H J WeinmannH Gries
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M MoriK Ogawa
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·G PaumgartnerG Grabner
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·E JacqueminPeter J Meier
Aug 1, 1996·Academic Radiology·C de HaënP Tirone
Oct 23, 1997·The Journal of Biological Chemistry·L M SatlinAllan W Wolkoff
Apr 26, 2000·The Journal of Biological Chemistry·Jörg KönigDietrich Keppler
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karin FattingerBruno Stieger
Jan 13, 2001·The Journal of Biological Chemistry·Y CuiDietrich Keppler
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gernot ZollnerMichael Trauner
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephan R VavrickaKarin Fattinger
Jan 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Deb S ShermanIsaac Teitelbaum
May 24, 2003·Journal of Hepatology·Gernot ZollnerMichael Trauner
Oct 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·H O WHEELERJ I MELTZER
Aug 1, 1960·The Journal of Clinical Investigation·B COMBES, G S STAKELUM
Apr 6, 2004·The Surgical Clinics of North America·Philip D Schneider
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Verena KeitelRalf Kubitz
Mar 15, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Ernst Petzinger, Joachim Geyer
Jun 27, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Evangelos CholongitasAndrew K Burroughs
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yvonne MeierBruno Stieger
Feb 14, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Annick SeithelJörg König
Mar 1, 2007·Current Opinion in Critical Care·Samir G Sakka
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Wei ZhangHong-Hao Zhou
Feb 23, 2008·Seminars in Liver Disease·François Durand, Dominique Valla
May 30, 2008·Clinical Pharmacology and Therapeutics·R M FrankeA Sparreboom
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Bruno Hagenbuch, Chunshan Gui
Jan 9, 2009·American Journal of Physiology. Cell Physiology·Simone LeutholdBruno Stieger
Jan 28, 2009·World Journal of Surgery·Stefan BreitensteinPierre Alain Clavien
May 6, 2009·Human Molecular Genetics·Andrew D JohnsonJacqueline C Witteman
Sep 30, 2009·British Journal of Pharmacology·A Kalliokoski, Mikko Niemi
Nov 26, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wilmar de GraafThomas M van Gulik
Jan 19, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wilmar de GraafRoelof J Bennink

Citations

Nov 8, 2013·Pflügers Archiv : European journal of physiology·M Sawkat Anwer, Bruno Stieger
Mar 20, 2013·Molecular Aspects of Medicine·Bruno Hagenbuch, Bruno Stieger
Jun 10, 2015·World Journal of Surgical Oncology·Shingo ShimadaMitsuo Kusano
Apr 17, 2012·Journal of Hepatology·Bernard E Van BeersHero K Hussain
Apr 8, 2017·Journal of Pharmaceutical Sciences·Bruno Stieger, Zainab M Mahdi
Oct 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ghulam MurtazaMariam
Oct 27, 2016·F1000Research·Bruno Stieger, Bruno Hagenbuch
Jan 25, 2019·Nuclear Medicine Communications·Fadi RassamRoel J Bennink
Jan 9, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Catherine M PastorBruno Stieger
Sep 25, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Bruno StiegerHariprasad Gali
May 23, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Katrin WlcekBruno Stieger
Sep 4, 2015·The Journal of Pharmacology and Experimental Therapeutics·Michele VisentinGerd A Kullak-Ublick
Jan 13, 2016·World Journal of Gastroenterology : WJG·Christoph G DietrichAndreas Geier
Jul 25, 2019·Sensors·Elżbieta KuberaTomasz Słowik
Sep 21, 2016·Annual Review of Pharmacology and Toxicology·Bruno StiegerWalter Jäger
Feb 26, 2015·Current Opinion in Gastroenterology·Steve HelmkeGregory T Everson
Mar 31, 2021·The Journal of Pharmacology and Experimental Therapeutics·Michele LeuenbergerMartin Lochner

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