The emerging roles of extracellular vesicles in diabetes and diabetic complications

Clinica Chimica Acta; International Journal of Clinical Chemistry
Fan ZhouChi Zhang

Abstract

Diabetes and diabetic vascular complications are now the leading cause of death in the world. The effects of traditional medical treatment are usually limited and accompanied by many side effects, such as hypoglycemia, obesity, liver and kidney damage, and gastrointestinal adverse reactions. Thus, it is urgent to explore some new strategies for the treatment of patients with diabetes. Recently, extracellular vesicles have received increased attention because of their emerging roles of cell-to-cell communication under physiological and pathological conditions. In addition, because of their abundant existence in almost all body fluids, as well as their plentiful cargos of bioactive proteins and miRNAs they carry, extracellular vesicles have a strong potential for therapeutic and diagnostic applications in many metabolic diseases, such as obesity and insulin resistance. Here, with the aim of providing the basis for the development of new treatments for diabetes, we review current understanding of extracellular vesicles and the critical roles it has played in the onset and progression of diabetes and diabetic complications.

Citations

Apr 30, 2020·American Journal of Physiology. Cell Physiology·Nicole Noren Hooten, Michele K Evans
Sep 10, 2020·Journal of Crohn's & Colitis·M ValterI Cleynen

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