The emerging roles of inositol pyrophosphates in eukaryotic cell physiology

Journal of Biosciences
Swarna Gowri Thota, Rashna Bhandari

Abstract

Inositol pyrophosphates are water soluble derivatives of inositol that contain pyrophosphate or diphosphate moieties in addition to monophosphates. The best characterised inositol pyrophosphates, are IP7 (diphosphoinositol pentakisphosphate or PP-IP5), and IP8 (bisdiphosphoinositol tetrakisphosphate or (PP)2-IP4). These energy-rich small molecules are present in all eukaryotic cells, from yeast to mammals, and are involved in a wide range of cellular functions including apoptosis, vesicle trafficking, DNA repair, osmoregulation, phosphate homeostasis, insulin sensitivity, immune signalling, cell cycle regulation, and ribosome synthesis. Identified more than 20 years ago, there is still only a rudimentary understanding of the mechanisms by which inositol pyrophosphates participate in these myriad pathways governing cell physiology and homeostasis. The unique stereochemical and bioenergetic properties these molecules possess as a consequence of the presence of one or two pyrophosphate moieties in the vicinity of densely packed monophosphates are likely to form the molecular basis for their participation in multiple signalling and metabolic pathways. The aim of this review is to provide first time researchers in this area with an ...Continue Reading

References

Aug 31, 1992·Biochemical and Biophysical Research Communications·S M VoglmaierA B Theibert
Jan 31, 1991·Biochemical and Biophysical Research Communications·K TakazawaC Erneux
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T Yoko-oA Toh-e
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·S M VoglmaierS H Snyder
May 17, 1996·The Journal of Biological Chemistry·M P Wilson, P W Majerus
Apr 3, 2001·Cellular Signalling·S B Shears
May 2, 2001·Nature Reviews. Molecular Cell Biology·R F Irvine, M J Schell
Aug 15, 2001·The Journal of Biological Chemistry·A SaiardiS H Snyder
Jun 27, 2002·The Journal of Biological Chemistry·John W VerbskySusan R Wente
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Adolfo SaiardiSolomon H Snyder
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Michael J BerridgeH Llewelyn Roderick
Mar 3, 2004·The Biochemical Journal·Christopher J BarkerRobert H Michell
Sep 8, 2004·Molecular Cell·Gregory J Miller, James H Hurley
Nov 9, 2004·The Journal of Biological Chemistry·John W VerbskyPhilip W Majerus
Nov 10, 2004·The Journal of Biological Chemistry·Eiichiro NagataSolomon H Snyder
Nov 25, 2004·The Journal of Biological Chemistry·Sally J YorkJohn D York
Dec 18, 2004·Science·Adolfo SaiardiSolomon H Snyder
Aug 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Adam C ResnickAdolfo Saiardi
Jan 24, 2006·Cellular and Molecular Life Sciences : CMLS·M BennettA Saiardi
May 17, 2006·Biochimica Et Biophysica Acta·Péter Várnai, Tamas Balla
Oct 19, 2006·Bioorganic & Medicinal Chemistry Letters·Christine E Hand, John F Honek
Oct 20, 2006·The Journal of Biological Chemistry·William Holmes, Gerwald Jogl

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Citations

Jan 14, 2016·ACS Chemical Biology·Lisa M Yates, Dorothea Fiedler
Jul 5, 2016·The International Journal of Biochemistry & Cell Biology·Sarbani GhoshalAnutosh Chakraborty
Nov 2, 2016·The Journal of Clinical Investigation·Qingzhang ZhuAnutosh Chakraborty
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Chunfang GuStephen B Shears
Jul 10, 2019·Scientific Reports·Almudena Escobar-NiñoFrancisco Javier Fernández-Acero
Mar 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sandip MukherjeeAnutosh Chakraborty
Apr 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·D Eric DollinsJohn D York
Jul 31, 2016·The Biochemical Journal·Manasa ChanduriRashna Bhandari
Dec 29, 2017·Biological Reviews of the Cambridge Philosophical Society·Anutosh Chakraborty
Dec 14, 2018·Frontiers in Plant Science·Ringo van WijkTeun Munnik
Aug 28, 2018·Bio-protocol·Miranda Sc Wilson, Adolfo Saiardi
Jun 14, 2019·Chemical Science·Robert K HarmelDorothea Fiedler
Feb 11, 2016·Biochemical Society Transactions·Thomas M LivermoreAdolfo Saiardi
Jan 1, 2017·Journal of the Indian Institute of Science·Akruti ShahRashna Bhandari
Aug 7, 2018·MedChemComm·Andrew M RileyBarry V L Potter
Apr 24, 2020·Current Genetics·Victoria A Morrissette, Ronda J Rolfes
Nov 2, 2019·Advances in Biological Regulation·Shubhra GanguliRashna Bhandari
Aug 14, 2020·Cell Chemical Biology·David FurkertDorothea Fiedler
Oct 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mirko MininiMariano Bizzarri
Apr 7, 2021·The Biochemical Journal·Padmavathi LollaRashna Bhandari
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raja MohanraoKana M Sureshan
Aug 29, 2019·Biochemistry·Robert PuschmannDorothea Fiedler
Aug 3, 2018··Adolfo SaiardiMiranda Wilson

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