The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Yasuhisa IwaoTatsuo Yamamoto

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a major concern worldwide. In the United States, ST8 CA-MRSA with SCCmecIVa (USA300) has been predominant, affecting the entire United States. In this study, we investigated Japanese ST8 CA-MRSA with new SCCmecIVl (designated ST8 CA-MRSA/J), which has emerged in Japan since 2003. Regarding community spread and infections, ST8 CA-MRSA/J spread in 16.2-34.4% as a major genotype in the community in Japan, and was associated with skin and soft tissue infections (SSTIs), colitis, and invasive infections (sepsis, epidural abscesses, and necrotizing pneumonia), including influenza prodrome cases and athlete infections, similar to USA300. It spread to even public transport and Hong Kong through a Japanese family. Regarding genetic diversity, ST8 CA-MRSA/J included ST and spa variants and was classified into at least three pulsed-field gel electrophoresis types, ST8 Jα to γ. Of those, ST8 Jβ was associated with severe invasive infections. As for genomics, ST8 CA-MRSA/J showed high similarities to USA300, but with marked diversity in accessory genes; e.g., ST8 CA-MRSA/J possessed enhanced cytolytic peptide genes of CA-MRSA, but lacked the Panton-Valentine...Continue Reading

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Citations

Jul 6, 2013·The Lancet Infectious Diseases·Yu-Yu Chuang, Yhu-Chering Huang
Jul 12, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroyoshi KinoAkira Matsumura
Oct 8, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shigeru FujimuraAkira Watanabe
Feb 2, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Wei-Chun HungTatsuo Yamamoto
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Oct 17, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Tsai-Wen WanTatsuo Yamamoto

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