The Emerging Therapeutic Role of NGF in Alzheimer's Disease

Neurochemical Research
Chao-Jin XuWei-Lin Jin

Abstract

Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology, mechanisms and symptoms of AD. Therefore, there is a need to summarize the new advancements in NGF research and its potential therapeutic implications in AD. In this review, we will focus on NGF distribution, production, and function; the interaction of Aβ and NGF; and the effect of different therapy methods on AD. In summary, we hope to describe the experimental and clinical data demonstrating the important roles of NGF for AD treatment.

References

Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·S ByravanA T Campagnoni
Jan 1, 1995·Alzheimer Disease and Associated Disorders·C Geula, M M Mesulam
Sep 1, 1996·Brain & Development·E C YuenW C Mobley
Oct 12, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Russo-NeustadtC W Cotman
Dec 29, 1999·Brain Research·A J KastinW A Banks
Oct 24, 2000·Brain Research. Developmental Brain Research·F CirulliL Aloe
Jun 12, 2001·Current Opinion in Neurobiology·A Patapoutian, L F Reichardt
Dec 1, 2001·Science·R LeeB L Hempstead
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keiko KawamotoHiroshi Matsuda
Jul 12, 2002·Journal of Neuroscience Research·Yangzhou Du, Cheryl F Dreyfus
Oct 3, 2002·Molecular and Cellular Neurosciences·Simona CapsoniAntonino Cattaneo
Sep 23, 2003·Journal of Molecular Neuroscience : MN·Stephen M MassaFrank M Longo
Oct 8, 2003·Current Drug Targets. CNS and Neurological Disorders·Shivanand P LadElliott J Mufson
Jan 1, 2004·Progress in Brain Research·Margaret FahnestockMichael D Coughlin
Jan 31, 2004·European Journal of Pharmacology·Dane R ListonW Frost White
Mar 1, 1951·The Journal of Experimental Zoology·R LEVI-MONTALCINI, V HAMBURGER
Feb 27, 2004·Nature·Anders NykjaerClaus M Petersen
Jun 25, 2004·American Journal of Alzheimer's Disease and Other Dementias·Simona CapsoniAntonino Cattaneo
Apr 27, 2005·Nature Medicine·Mark H TuszynskiJames Conner
May 27, 2005·Psychopharmacology·Undine E LangJürgen Gallinat
Feb 9, 2006·Neurological Research·Jianchun YuJingxian Han
Oct 1, 1954·Proceedings of the National Academy of Sciences of the United States of America·S CohenV Hamburger
Jul 11, 2006·Neuro-Signals·Klaus HeeseNoriko Inoue
Jun 29, 2007·Journal of Molecular Biology·Masaki Wakabayashi, Katsumi Matsuzaki
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Carmela MatronePietro Calissano
Dec 10, 2008·BMC Medical Genetics·Denis A AkkadJörg T Epplen
Jun 6, 2009·International Journal of Clinical Practice·M S LeeE Ernst
Jun 16, 2009·Neurotoxicity Research·Barbara L Hempstead
Jul 17, 2009·Journal of Neuropathology and Experimental Neurology·Martin A BrunoA Claudio Cuello
Aug 15, 2009·Neurotoxicity Research·Yan-Jiang WangXin-Fu Zhou
Aug 15, 2009·Journal of Molecular Neuroscience : MN·A Claudio CuelloM Florencia Iulita
Jan 6, 2010·Journal of Neurochemistry·Maria-Angeles ArevaloAlfredo Rodríguez-Tebar
Mar 17, 2010·Molecular Neurodegeneration·Marwa AboukhatwaYuan Luo
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-Jiang WangXin-Fu Zhou

❮ Previous
Next ❯

Citations

Jun 20, 2016·European Journal of Medicinal Chemistry·Jaana Tammiku-TaulMati Karelson
Sep 15, 2018·Experimental and Therapeutic Medicine·Wei ChenShiwei Duan
Sep 12, 2017·Journal of Integrative Neuroscience·Zübeyde ErbayraktarN Nuray Ulusu
Aug 15, 2018·International Journal of Molecular Sciences·Antonio Magrì, Diego La Mendola
Aug 11, 2020·Reviews in the Neurosciences·Hamidreza ArzaghiHamidreza Pazoki-Toroudi
Dec 2, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jun-Ling Wang, Chao-Jin Xu
Jun 11, 2021·Journal of Natural Medicines·Kohsuke ShimomuraShigenori Kumazawa
Jul 10, 2021·Oxidative Medicine and Cellular Longevity·Md Sahab UddinMohamed M Abdel-Daim
Sep 9, 2021·Journal of Cellular Biochemistry·Priyanka Madhu, Samrat Mukhopadhyay
Dec 7, 2021·Frontiers in Neurology·Katharina Steiner, Christian Humpel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Current Opinion in Ophthalmology
Alessandro LambiaseStefano Bonini
Médecine sciences : M/S
Fabien GosseletLaurence Fenart
© 2022 Meta ULC. All rights reserved