The emerging use of bioluminescence in medical research

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Sana SharifianKhosro Khajeh

Abstract

Bioluminescence is the light produced by a living organism and is commonly emitted by sea life with Ca2+-regulated photoproteins being the most responsible for bioluminescence emission. Marine coelenterates provide important functions involved in essential purposes such as defense, feeding, and breeding. In this review, the main characteristics of marine photoproteins including aequorin, clytin, obelin, berovin, pholasin and symplectin from different marine organisms will be discussed. We will focused on the recent use of recombinant photoproteins in different biomedical research fields including the measurement of Ca2+ in different intracellular compartments of animal cells, as labels in the design and development of binding assays. This review will also outline how bioluminescent photoproteins have been used in a plethora of analytical methods including ultra-sensitive assays and in vivo imaging of cellular processes. Due to their unique properties including elective intracellular distribution, wide dynamic range, high signal-to-noise ratio and low Ca2+-buffering effect, recombinant photoproteins represent a promising future analytical tool in several in vitro and in vivo experiments.

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Citations

Jun 6, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Meng GaoYa-Jun Liu
Dec 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Carola GregorStefan W Hell
Apr 3, 2020·Micromachines·Muqsit Pirzada, Zeynep Altintas
Sep 13, 2019·International Journal of Molecular Sciences·Nadezhda S Kudryasheva, Ekaterina S Kovel
Oct 30, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Rashmi A WanjariSanjay J Dhoble
Oct 18, 2019·International Journal of Biological Macromolecules·Sana SharifianSeema Patel
Jul 25, 2021·International Journal of Molecular Sciences·Natthaphat Siri-AngkulJudith K Gwathmey
Sep 15, 2021·The Journal of Physical Chemistry. B·Shu-Feng ChenYa-Jun Liu
Nov 26, 2021·Bioprocess and Biosystems Engineering·Sudabeh IraninasabHafiz M N Iqbal

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