The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review

Technology in Cancer Research & Treatment
Jianxiang Zhang, Lingyu Wang

Abstract

T-cell receptor-engineered T-cell therapy and chimeric antigen receptor T-cell therapy are 2 types of adoptive T-cell therapy that genetically modify natural T cells to treat cancers. Although chimeric antigen receptor T-cell therapy has yielded remarkable efficacy for hematological malignancies of the B-cell lineages, most solid tumors fail to respond significantly to chimeric antigen receptor T cells. T-cell receptor-engineered T-cell therapy, on the other hand, has shown unprecedented promise in treating solid tumors and has attracted growing interest. In order to create an unbiased, comprehensive, and scientific report for this fast-moving field, we carefully analyzed all 84 clinical trials using T-cell receptor-engineered T-cell therapy and downloaded from ClinicalTrials.gov updated by June 11, 2018. Informative features and trends were observed in these clinical trials. The number of trials initiated each year is increasing as expected, but an interesting pattern is observed. NY-ESO-1, as the most targeted antigen type, is the target of 31 clinical trials; melanoma is the most targeted cancer type and is the target of 33 clinical trials. Novel antigens and underrepresented cancers remain to be targeted in future studies a...Continue Reading

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Clinical Trials Mentioned

NCT03578406
NCT03503968
NCT02743611
NCT03139370
NCT03247309
NCT02592577
NCT01343043
NCT01892293
NCT01352286
NCT01567891

Software Mentioned

ACTengine
Adaptimmune
CaspaCIDe
GENErator
TraCeR
Medigene

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