The ENaC channel is required for normal epidermal differentiation

The Journal of Investigative Dermatology
T MauroE Hummler

Abstract

Ionic fluxes are important for critical aspects of keratinocyte differentiation, including synthesis of differentiation-specific proteins, enzymatic catalysis of protein cross-linking, post-transcriptional processing of profilaggrin, and lipid secretion. The epithelial sodium channel is expressed in epidermis and the expression of its alpha and beta subunits is enhanced as keratinocytes differentiate. In order to ascertain the role of the epithelial sodium channel in epidermal differentiation, we examined skin of mice in which the epithelial sodium channel alpha subunit had been deleted. Newborn -/- mice, in which the alpha subunit had been completely inactivated, demonstrated epithelial hyperplasia, abnormal nuclei, premature secretion of lipids, and abnormal keratohyaline granules. In addition, immunohistochemistry demonstrated that expression of the differentiation markers K1, K6, and involucrin were abnormal. These data suggest that the epithelial sodium channel modulates ionic signaling for specific aspects of epidermal differentiation, such as synthesis or processing of differentiation- specific proteins, and lipid secretion.

References

Apr 1, 1975·The Journal of Cell Biology·P M Elias, D S Friend
Feb 1, 1992·The Journal of Clinical Investigation·S H LeeK R Feingold
Sep 1, 1983·Journal of Cellular Physiology·H HenningsS H Yuspa
Jan 1, 1995·The Journal of Investigative Dermatology·S A GrandoM V Dahl
Aug 11, 1995·Science·M J StuttsR C Boucher
Mar 1, 1993·The Journal of Membrane Biology·T M MauroP A Pappone
Feb 1, 1995·The Journal of Investigative Dermatology·R B PreslandB A Dale
Jun 1, 1994·The Journal of Investigative Dermatology·S H LeeT Mauro
Apr 1, 1997·Physiological Reviews·H Garty, L G Palmer
Jun 1, 1997·The Journal of Investigative Dermatology·T MauroP A Pappone
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·E HummlerB C Rossier
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·F J McDonaldR A Williamson
Mar 17, 1999·The Journal of Comparative Neurology·W LinS C Kinnamon
Jun 22, 1999·Experimental Eye Research·M MirshahiM K Agarwal
Aug 26, 1999·Skin Pharmacology and Applied Skin Physiology·D Wohlrab, F Markwardt
Nov 26, 1999·The Journal of Investigative Dermatology·Y OdaT Mauro

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Citations

Apr 21, 2011·Nature Communications·Natasha A BoaseSharad Kumar
Jul 9, 2004·Molecular Biology of the Cell·James A McCormickDavid Pearce
Jul 5, 2011·Annual Review of Cell and Developmental Biology·Roman Szabo, Thomas H Bugge
Mar 1, 2013·Journal of Cell Science·Hsin-Ya YangR Rivkah Isseroff
Aug 3, 2005·The Journal of Cell Biology·Céline LeyvrazEdith Hummler
Sep 4, 2009·Trends in Biochemical Sciences·Petra OvaereWim Declercq
Jul 4, 2003·The Journal of Investigative Dermatology·Sahba FatheraziKenneth T Izutsu
Feb 11, 2015·The Journal of Investigative Dermatology·Eve MaubecNicolette Farman
Oct 28, 2008·European Journal of Pharmacology·Hisao YamamuraShoichi Shimada
Jun 17, 2008·Biochemical and Biophysical Research Communications·Hisao YamamuraShoichi Shimada
Nov 21, 2009·Experimental Dermatology·Nicolette FarmanRalf Paus
Jun 29, 2004·Hearing Research·Shi-Xun Zhong, Zhao-Hua Liu
Dec 13, 2007·Biochemical and Biophysical Research Communications·Hisao YamamuraShoichi Shimada
Jun 10, 2016·British Journal of Pharmacology·Emilie BoscardinStephan Kellenberger
Mar 7, 2007·Current Topics in Developmental Biology·Carole Planès, George H Caughey
Nov 6, 2015·Science Translational Medicine·Wei XuThomas A Mustoe
Feb 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jens TitzeKarl F Hilgers
Sep 24, 2004·Physiological Reviews·Popi Syntichaki, Nektarios Tavernarakis
Apr 9, 2005·The Journal of Biological Chemistry·Vadim ShlyonskySarah Sariban-Sohraby
Sep 30, 2005·Journal of the American Society of Nephrology : JASN·Edith Hummler, Volker Vallon
Nov 2, 2005·Inflammopharmacology·Yasuhiro FujiwaraTetsuo Arakawa
Nov 28, 2007·The Journal of Biological Chemistry·Roch-Philippe CharlesEdith Hummler
Jun 16, 2004·American Journal of Physiology. Cell Physiology·Mouhamed S AwaydaRoy C Orlando
Apr 30, 2020·Experimental Dermatology·Andrew TouatiJouni Uitto
Jun 26, 2015·Current Opinion in Allergy and Clinical Immunology·Yee Kiat Heng, Yen Loo Lim
Nov 14, 2017·Skin Pharmacology and Physiology·Iga Hołyńska-IwanDorota Olszewska-Słonina
Mar 16, 2004·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Marjorie GuitardEdith Hummler
Mar 3, 2012·Experimental Dermatology·Nina KirschnerJohanna M Brandner
Dec 15, 2010·The Journal of Biological Chemistry·Stine FriisLotte K Vogel
Jan 29, 2017·Histochemistry and Cell Biology·Israel HanukogluAaron Hanukoglu
Feb 22, 2002·Genesis : the Journal of Genetics and Development·Edith HummlerFriedrich Beermann
Nov 18, 2021·British Journal of Pharmacology·Paloma Pérez

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