The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined.

Seminars in Pediatric Neurology
Joseph J Volpe

Abstract

The field of neonatal neurology, and specifically its focus on the premature infant, had its inception in neuropathologic studies. Since then, the development of advanced imaging techniques has guided our developing understanding of the etiology and nature of neonatal brain injury. This review promotes the concept that neonatal brain injury has serious and diverse effects on subsequent brain development, and that these effects likely are more important than simple tissue loss in determining neurologic outcome. Brain injury in the premature infant is best illustrative of this concept. This "encephalopathy of prematurity" is reviewed in the context of the remarkable array of developmental events actively proceeding during the last 16-20 weeks of human gestation. Recent insights into the brain abnormalities in survivors of preterm birth obtained by both advanced magnetic resonance imaging and neuropathologic techniques suggest that this encephalopathy is a complex amalgam of destructive and developmental disturbances. The interrelations between destructive and developmental mechanisms in the genesis of the encephalopathy are emphasized. In the future, advances in neonatal neurology will likely reiterate the dependence of this fiel...Continue Reading

References

Jun 1, 1987·American Journal of Diseases of Children·D L ArmstrongJ Goddard-Finegold
Sep 1, 1970·Experimental Neurology·J DobbingJ Sands
Nov 15, 1996·Journal of Neuroscience Research·A YoshiokaD Pleasure
Mar 1, 1997·Journal of Neuropathology and Experimental Neurology·M Marín-Padilla
Oct 20, 1998·Seminars in Pediatric Neurology·H C Kinney, S A Back
Dec 8, 1998·Journal of Neuroscience Research·T AndrewsN R Bhat
Jun 17, 1999·Pediatric Neurology·K DeguchiS Takashima
Sep 15, 1999·The Journal of Pediatrics·E F MaaloufA D Edwards
Oct 16, 1999·Journal of Neuroscience Methods·S A BackJ J Volpe
Mar 30, 2000·Journal of Neurocytology·C BjartmarB D Trapp
Jun 1, 2000·Pediatric Research·E B IsaacsD G Gadian
Oct 18, 2000·JAMA : the Journal of the American Medical Association·B S PetersonL R Ment
Mar 16, 2001·Trends in Neurosciences·C MatuteM V Sánchez-Gómez
Jul 21, 2001·Developmental Medicine and Child Neurology·Y LinK Watanabe
Aug 31, 2001·Nature Neuroscience·K Letinic, P Rakic
Jun 7, 2002·Nature·Seong-Seng Tan
Jun 7, 2002·Nature·Kresimir LetinicPasko Rakic
Jun 22, 2002·Brain : a Journal of Neurology·Chiara NosartiRobin M Murray
Jul 12, 2002·Journal of Neuroscience Research·Yangzhou Du, Cheryl F Dreyfus
Oct 31, 2002·Journal of Neuroscience Research·Michael J Bell, John M Hallenbeck
Nov 20, 2002·Pediatric Research·Jhodie R DuncanSandra M Rees
Nov 27, 2002·Journal of Magnetic Resonance Imaging : JMRI·Steven P MillerA James Barkovich
Dec 28, 2002·Journal of Neuroscience Research·Paul A RosenbergJoseph J Volpe
Feb 19, 2003·Nature Genetics·Corinna Lappe-SiefkeKlaus-Armin Nave
Mar 5, 2003·Brain, Behavior, and Immunity·Serge Rivest
May 9, 2003·Pediatric Research·Stephane V SizonenkoChris Williams
May 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wenbin DengFrances E Jensen
May 29, 2003·Journal of Neuropathology and Experimental Neurology·Robin L HaynesHannah C Kinney
Jun 24, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·T DebillonJ C Roze
Jun 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Seija LehnardtTimothy Vartanian

❮ Previous
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Citations

Mar 20, 2014·Pain Management·Manon Ranger, Ruth E Grunau
Apr 9, 2013·Future Neurology·Mibel M Pabon, Cesar V Borlongan
Apr 10, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Michela GroppoA David Edwards
Jan 1, 2013·Early Human Development·Knut Jørgen BjulandJon Skranes
Jul 1, 2014·Early Human Development·Ines Mürner-LavanchyRegula Everts
Jul 16, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Peter WuKathryn McFadden
Dec 1, 2011·Acta Informatica Medica : AIM : Journal of the Society for Medical Informatics of Bosnia & Herzegovina : časopis Društva Za Medicinsku Informatiku BiH·Sanja Tomasovic, Maja Predojevic
May 18, 2010·Journal of Neural Transmission·Vincent DegosPierre Gressens
Oct 16, 2012·Neuropsychology Review·Carly MolloyPeter J Anderson
May 1, 2010·Pediatric Radiology·Maria I Argyropoulou
Jan 12, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Pier Paolo BassareoGiuseppe Mercuro
Aug 24, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·M M A RaetsP Govaert
Jan 17, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Lars M RimolJon Skranes
Mar 1, 2011·Expert Opinion on Medical Diagnostics·Topun Austin, Helen O'Reilly
Jan 24, 2015·NeuroImage·Yuning ZhangDavid C Van Essen
Feb 15, 2014·Clinics in Perinatology·Manon J N L BendersLinda S de Vries
Aug 29, 2012·Molecular and Cellular Neurosciences·H B Stolp
Jun 20, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Simona OrcesiMauro Stronati
Feb 11, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jasenka SarajlijaCarlo Alberto Tassinari
Dec 10, 2015·Early Human Development·Flavia M WehrleCornelia F Hagmann
Oct 17, 2012·Developmental Medicine and Child Neurology·Martin de Kleine
Jul 31, 2013·Developmental Medicine and Child Neurology·Jorrit F de Kieviet
Oct 5, 2011·Developmental Medicine and Child Neurology·Gerda van Wezel-MeijlerJeroen Van der Grond
Oct 18, 2011·Annals of Neurology·Justin M DeanCarina Mallard
Jan 19, 2011·Acta Paediatrica·Ghada BeainoUNKNOWN EPIPAGE Study Group
Jan 15, 2011·Developmental Medicine and Child Neurology·Joel M WeinsteinJeremy D Fesi
Jan 18, 2015·Cerebral Cortex·Gareth BallSerena J Counsell
Jul 27, 2011·IEEE Transactions on Medical Imaging·P AljabarD Rueckert
Sep 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Jonathan J HirstHannah K Palliser
Sep 27, 2015·Journal of Neuroinflammation·Chen JinGregory A Lodygensky
Jun 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kristen EmpieSandra E Juul
Aug 8, 2015·Clinics in Perinatology·Sandra E Juul, Gillian C Pet

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