The encephalopathy of prematurity: one pediatric neuropathologist's perspective.

Seminars in Pediatric Neurology
Hannah C Kinney

Abstract

A major challenge in understanding brain injury in the premature brain is the establishment of the precise human neuropathology at the cellular and molecular levels, as such knowledge is the foundation upon which the elucidation of the cause(s), scientific experimentation, and therapies in the field is by necessity based. In this essay, I provide my perspective as a pediatric neuropathologist upon pathologic studies in the developing human brain itself, including a review of past, present, and future aspects. My focus is upon the path that has brought us to the current recognition that preterm brain injury is a complex of white and gray matter damage that results in the modification of key developmental pathways during a critical period, which in turn defines the adverse clinical outcomes as important as the primary insult itself. The evolution of this recognition, as well as the introduction of the term "encephalopathy of prematurity" for the complex of gray and white matter damage because of acquired and developmental mechanisms, is discussed. Our enhanced understanding of the fundamental neuropathology of the human preterm brain should bring us closer to more effective therapy as the need to prevent and treat injury to devel...Continue Reading

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Citations

Oct 7, 2010·Pediatric Research·Robin L HaynesHannah C Kinney
Oct 30, 2010·Disease Models & Mechanisms·John C SilbereisDavid H Rowitch
Jun 12, 2012·Neurology Research International·Hannah C Kinney, Joseph J Volpe
Apr 25, 2012·Neurology Research International·Ryan M McAdams, Sandra E Juul
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May 25, 2010·Developmental Medicine and Child Neurology·Andreia Vaconcellos Faria, Alec Hoon
Jan 1, 2015·Vestnik otorinolaringologii·I V Savenko, M Yu Boboshko
Nov 18, 2018·Pediatric Research·Cindy BokobzaPierre Gressens
Apr 4, 2019·Frontiers in Behavioral Neuroscience·Cecil M Y ChauRuth E Grunau
Jul 6, 2011·Archives of General Psychiatry·Agnes H WhitakerNigel Paneth
Nov 5, 2013·Clinics in Perinatology·Robin L HaynesHannah C Kinney
Aug 27, 2021·Annals of Neurology·Dalit Cayam-RandSteven P Miller

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