Abstract
Trials in adults have demonstrated that interventions targeting lifestyle are effective in preventing or delaying type 2 diabetes (T2D). To address this need in youth, we developed ENCOURAGE Healthy Families (ENCOURAGE), based on the US Diabetes Prevention Program (DPP). Here, we present results of the ENCOURAGE randomized, comparative effectiveness trial in which we evaluated ENCOURAGE delivered to (1) mothers only, and (2) mothers with added content delivered to their children. The study was performed in Indianapolis, IN, at an academic medical center and the YMCA; December 2012 to April 2016. Women with a history of gestational diabetes mellitus (GDM) or prediabetes with children aged 8 to 15 years enrolled (n = 128). Outcomes were collected at baseline, postintervention (3 months), 6 and 12 months. The primary outcome was weight change at 3 months in adults; secondary outcomes included glycosylated hemoglobin (HbA1c), lipids, and blood pressure. In neither program did mothers' weight change. HbA1c decreased at 3 months in both groups (mothers only=-0.09%, P = .019; mothers and children=-0.11%, P = .003). Participating children had a reduction in body mass index (BMI) percentile at 3 (-1.77, P = .014), 6 (-3.0, P = .002), an...Continue Reading
References
Nov 25, 2000·Diabetes Care
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
May 6, 2003·Current Diabetes Reports·Jaakko Tuomilehto, Jaana Lindström
Feb 26, 2004·Obesity Research·Moria Golan, Scott Crow
Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
Mar 5, 2005·Journal of the American Dietetic Association·Mary SavoyeSonia Caprio
Jul 28, 2005·Diabetes·Abbas E KitabchiUNKNOWN Diabetes Prevention Program Research Group
Nov 14, 2006·Lancet·Jaana LindströmUNKNOWN Finnish Diabetes Prevention Study Group
May 12, 2007·International Journal of Technology Assessment in Health Care·Peter LindgrenUNKNOWN DPS Study Group
Jun 28, 2007·JAMA : the Journal of the American Medical Association·Mary SavoyeSonia Caprio
Feb 27, 2008·Diabetes Care·Dana Dabelea
Jul 4, 2007·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Leonard H EpsteinMeghan D Beecher
Oct 2, 2007·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Moria Golan
Feb 2, 2008·Obesity·Leonard H EpsteinJames N Roemmich
Mar 22, 2008·Obesity·Elissa JelalianRena R Wing
Apr 1, 2008·Diabetes Care·Dana DabeleaRichard F Hamman
May 21, 2008·Annals of Internal Medicine·Teresa A HillierDavid J Pettitt
Sep 10, 2008·American Journal of Preventive Medicine·Ronald T AckermannDavid G Marrero
Nov 3, 2009·Lancet·William C KnowlerDavid M Nathan
Nov 21, 2009·Clinical Chemistry·Erna Lenters-Westra, Robbert J Slingerland
Jun 29, 2010·The New England Journal of Medicine·UNKNOWN HEALTHY Study GroupKathryn Hirst
Jul 29, 2010·Diabetes Care·Timo SaaristoSirkka Keinänen-Kiukaanniemi
Oct 22, 2010·The Journal of Clinical Endocrinology and Metabolism·Kenneth C CopelandUNKNOWN TODAY Study Group
Feb 9, 2011·Pediatrics·Mary SavoyeSonia Caprio
Jun 15, 2011·Journal of the National Medical Association·Deborah L BurnetMarshall H Chin
Jun 29, 2011·Diabetes·Dana Dabelea, Tessa Crume
Oct 25, 2012·Diabetologia·J LindströmUNKNOWN Finnish Diabetes Prevention Study (DPS)
Nov 23, 2012·Diabetes Care·Giuseppina ImperatoreUNKNOWN SEARCH for Diabetes in Youth Study Group
Sep 26, 2013·Diabetes Care·Mary SavoyeWilliam V Tamborlane
May 6, 2014·JAMA : the Journal of the American Medical Association·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Moshe HodLuis Cabero-Roura