The endocannabinoid-alcohol crosstalk: Recent advances on a bi-faceted target

Clinical and Experimental Pharmacology & Physiology
Gianluca LavancoCarla Cannizzaro

Abstract

Increasing evidence has focusesed on the endocannabinoid system as a relevant player in the induction of aberrant synaptic plasticity and related addictive phenotype following chronic excessive alcohol drinking. In addition, the endocannabinoid system is implicated in the pathogenesis of alcoholic liver disease. Interestingly, whereas the involvement of CB1 receptors in alcohol rewarding properties is established, the central and peripheral action of CB2 signalling is still to be elucidated. This review aims at giving the input to deepen knowledge on the role of the endocannabinoid system, highlighting the advancing evidence that suggests that CB1 and CB2 receptors may play opposite roles in the regulation of both the reinforcing properties of alcohol in the brain and the mechanisms responsible for cell injury and inflammation in the hepatic tissue. The manipulation of the endocannabinoid system could represent a bi-faceted strategy to counteract alcohol-related dysfunction in central transmission and liver structural and functional disarrangement.

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Citations

Oct 31, 2018·Cellular and Molecular Life Sciences : CMLS·Catherine DongVenkatesh L Hegde
Jan 1, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Lin YeYan Jiang
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Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis Santos-MolinaGrzegorz Godlewski

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