The endocannabinoid system: a new molecular target for the treatment of tobacco addiction.

CNS & Neurological Disorders Drug Targets
Maria SchermaG Tanda

Abstract

Tobacco addiction is one of the leading preventable causes of mortality in the world and nicotine appears to be the main critical psychoactive component in establishing and maintaining tobacco dependence. Several lines of evidence suggest that the rewarding effects of nicotine, which underlie its abuse potential, can be modulated by manipulating the endocannabinoid system. For example, pharmacological blockade or genetic deletion of cannabinoid CB(1) receptors reduces or eliminates many behavioral and neurochemical effects of nicotine that are related to its addictive potential. This review will focus on the recently published literature about the role of the endocannabinoid system in nicotine addiction and on the endocannabinoid system as a novel molecular target for the discovery of medications for tobacco dependence.

Citations

Mar 21, 2009·Psychopharmacology·Bernard Le FollSteven R Goldberg
Apr 8, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Miriam Melis, Marco Pistis
May 14, 2016·Current Addiction Reports·Punitha SubramaniamDeborah Yurgelun-Todd
Oct 3, 2013·Pharmacology, Biochemistry, and Behavior·Robert B RaffaScott M Rawls
Jun 1, 2012·The International Journal of Neuropsychopharmacology·María Jesús Luque-RojasEduardo Blanco Calvo
Sep 23, 2011·Journal of Psychopharmacology·Jose Antonio López-MorenoKora-Mareen Bühler
Aug 29, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leigh V Panlilio, Zuzana Justinova
Jan 3, 2018·Addiction Biology·Louise AdermarkBo Söderpalm
Apr 28, 2011·Addiction Biology·Islam GamaleddinBernard Le Foll
Jun 7, 2017·Reviews in the Neurosciences·Alireza MajdiSaeed Sadigh-Eteghad
Jul 17, 2019·Therapeutic Advances in Psychopharmacology·Harriet Quigley, James H MacCabe
Feb 15, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Javier Fernández-RuizManuel Guzmán

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