The Endocannabinoid System across Postnatal Development in Transmembrane Domain Neuregulin 1 Mutant Mice

Frontiers in Psychiatry
Rose ChesworthTim Karl

Abstract

The use of cannabis is a well-established component risk factor for schizophrenia, particularly in adolescent individuals with genetic predisposition for the disorder. Alterations to the endocannabinoid system have been found in the prefrontal cortex of patients with schizophrenia. Thus, we assessed whether molecular alterations exist in the endocannabinoid signalling pathway during brain development in a mouse model for the schizophrenia risk gene neuregulin 1 (Nrg1). We analysed transcripts encoding key molecules of the endocannabinoid system in heterozygous transmembrane domain Nrg1 mutant mice (Nrg1 TM HET), which is known to have increased sensitivity to cannabis exposure. Tissue from the prelimbic cortex and hippocampus of male and female Nrg1 TM HET mice and wild type-like littermates was collected at postnatal days (PNDs) 7, 10, 14, 21, 28, 35, 49, and 161. Quantitative polymerase chain reaction was conducted to assess mRNA levels of cannabinoid receptor 1 (CB1R) and enzymes for the synthesis and breakdown of the endocannabinoid 2-arachidonoylglycerol [i.e., diacylglycerol lipase alpha (DAGLα), monoglyceride lipase (MGLL), and α/β-hydrolase domain-containing 6 (ABHD6)]. No sex differences were found for any transcripts ...Continue Reading

References

Sep 29, 1999·Neuroreport·F M LewekeD Piomelli
Sep 9, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea GiuffridaDaniele Piomelli
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
Jun 25, 2005·Schizophrenia Bulletin·Cécile HenquetJim van Os
May 30, 2006·Biological Psychiatry·Consuelo Walss-BassHenriette Raventos
Nov 10, 2006·Hippocampus·Lydia DanglotSerge Marty
Jul 9, 2008·Archives of General Psychiatry·Stephen M EgganDavid A Lewis
Sep 20, 2008·Current Opinion in Neurobiology·Tibor HarkanyPatrick Doherty
Feb 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Huai-Xing Wang, Wen-Jun Gao
Jun 18, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen M EgganDavid A Lewis
Aug 4, 2010·Neuroscience·L DuffyT Karl
Aug 13, 2010·The International Journal of Neuropsychopharmacology·Aurélie A BoucherJonathon C Arnold
Feb 9, 2011·Archives of General Psychiatry·Matthew LargeOlav Nielssen
Apr 8, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Victoria S DaltonKaterina Zavitsanou
Jul 16, 2011·Trends in Pharmacological Sciences·Erik KeimpemaTibor Harkany
Sep 29, 2011·Behavioural Brain Research·Rose ChesworthTim Karl
Nov 23, 2011·The European Journal of Neuroscience·Madeleine J OudinPatrick Doherty
Jul 11, 2012·Pharmacology·Anne-Lise GaffuriZsolt Lenkei
Jul 26, 2012·BMC Neuroscience·Leonora E LongCynthia Shannon Weickert
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Javier Díaz-AlonsoIsmael Galve-Roperh
Mar 1, 2013·Frontiers in Cellular Neuroscience·Tim Karl, Jonathon C Arnold
Apr 9, 2013·Schizophrenia Research·David W VolkDavid A Lewis
Apr 16, 2013·Progress in Neurobiology·Bridgette D SempleLinda J Noble-Haeusslein
Jun 25, 2014·Molecular Psychiatry·R A PowerN G Martin
Jan 8, 2015·Frontiers in Behavioral Neuroscience·Tim Karl, Jonathon C Arnold

❮ Previous
Next ❯

Citations

Jan 31, 2020·The Journal of Comparative Neurology·Xue LiuLiping Wang
Jul 25, 2021·International Journal of Molecular Sciences·Citlalli NetzahualcoyotziMario Humberto Buenrostro-Jáuregui
Aug 21, 2021·Frontiers in Psychiatry·Lining DuanYousheng Mo

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved