The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases

Progress in Neurobiology
Valerio ChiurchiùMauro Maccarrone

Abstract

Multiple sclerosis is the most common inflammatory demyelinating disease of the central nervous system, caused by an autoimmune response against myelin that eventually leads to progressive neurodegeneration and disability. Although the knowledge on its underlying neurobiological mechanisms has considerably improved, there is a still unmet need for new treatment options, especially for the progressive forms of the disease. Both preclinical and clinical data suggest that cannabinoids, derived from the Cannabis sativa plant, may be used to control symptoms such as spasticity and chronic pain, whereas only preclinical data indicate that these compounds and their endogenous counterparts, i.e. the endocannabinoids, may also exert neuroprotective effects and slow down disease progression. Here, we review the preclinical and clinical studies that could explain the therapeutic action of cannabinoid-based medicines, as well as the medical potential of modulating endocannabinoid signaling in multiple sclerosis, with a link to other neuroinflammatory disorders that share common hallmarks and pathogenetic features.

Citations

Aug 10, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Heidi HögelLaura Airas
Sep 14, 2019·International Journal of Molecular Sciences·Giacomo GiacovazzoRoberto Coccurello
Sep 14, 2019·Future Medicinal Chemistry·Francesca GadoClementina Manera
Mar 10, 2020·CNS & Neurological Disorders Drug Targets·Andrea RomigiMauro Maccarrone
Aug 8, 2020·ChemMedChem·Samuele Maramai, Margherita Brindisi
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui S RodriguesSara Xapelli
May 31, 2019·Frontiers in Pharmacology·Maria Domenica SannaNicoletta Galeotti
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Matteo BaucknehtSilvia Morbelli
Apr 25, 2020·International Journal of Molecular Sciences·Naina Bhatia-Dey, Thomas Heinbockel
Jul 19, 2018·Frontiers in Neuroscience·Eva J van RoodenMario van der Stelt
Nov 13, 2018·Frontiers in Neuroscience·Alexander A IlyasovAllyn C Howlett
Jan 27, 2019·Developmental Medicine and Child Neurology·Suzanne NielsenWayne Hall
Mar 7, 2020·Frontiers in Cellular Neuroscience·Miriam MechaCarmen Guaza
Mar 22, 2018·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Leos LandaRegina Demlova
Mar 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kinga Fanni TóthAttila Oláh
Jul 18, 2020·Proceedings·Jennifer Clay Cather, J Christian Cather
Sep 26, 2020·The European Journal of Neuroscience·Tibor M Brunt, Matthijs G Bossong
Jul 1, 2020·Neurobiology of Disease·Carmen NavarreteEduardo Muñoz
Dec 29, 2020·Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï·H V KosiakovaA A Chumak
Aug 28, 2019·Progress in Neurobiology·Ying YuJianxiong Jiang
Sep 2, 2020·Annual Review of Pharmacology and Toxicology·Noëlle van EgmondMario van der Stelt
Jan 21, 2021·International Journal of Molecular Sciences·Anna StasiłowiczJudyta Cielecka-Piontek
Apr 27, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrícia AlvesGeorgina Correia-da-Silva
Mar 7, 2021·International Journal of Molecular Sciences·Tristyn L ClarkeRobert L Carlone
Apr 17, 2021·ACS Pharmacology & Translational Science·Ines Reynoso-MorenoAndrea Chicca
May 1, 2021·International Journal of Molecular Sciences·Estefanía MorenoEnric I Canela
May 2, 2021·Pharmacology, Biochemistry, and Behavior·Jenny L WilkersonLance R McMahon
Jun 6, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rebecca FerrisiFrancesca Gado
Aug 16, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefania SgroiAngelo Reggiani
Sep 8, 2021·Alzheimer's Research & Therapy·Kamil BorkowskiUNKNOWN Alzheimer’s Disease Metabolomics Consortium
Sep 21, 2021·Neuropathology and Applied Neurobiology·Marta TiberiValerio Chiurchiù

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.