The endocannabinoid system and NGF are involved in the mechanism of action of resveratrol: a multi-target nutraceutical with therapeutic potential in neuropsychiatric disorders

Psychopharmacology
Parichehr HassanzadehRassoul Dinarvand

Abstract

Resveratrol is a polyphenolic compound with antioxidant, anti-inflammatory, and neuroprotective effects. It has also shown antidepressant-like effects in the behavioral studies; however, its mechanism(s) of action merit further evaluation. The interaction between the nerve growth factor (NGF) and endocannabinoid system (eCBs) and their contribution to the antidepressant or emotional activity prompted us to evaluate their implications in the mechanism of action of resveratrol. After single and 4-week intraperitoneal (i.p.) once-daily injections of resveratrol (40, 80, and 100 mg/kg), amitriptyline (2.5, 5, and 10 mg/kg), or clonazepam (10, 20, and 40 mg/kg) into male Wistar rats, eCB and NGF contents were quantified in the brain regions implicated in the modulation of emotions by isotope-dilution liquid chromatography/mass spectrometry and Bio-Rad protein assay, respectively. In the case of any significant alteration of brain eCB or NGF level, the effect of pre-treatment with cannabinoid CB1 or CB2 receptor antagonist (AM251 or SR144528) was investigated. Four-week treatment with resveratrol or amitriptyline resulted in a significant and sustained enhancement of NGF and eCB contents in dose-dependent and brain region-specific ma...Continue Reading

References

Aug 1, 1992·Journal of Neuroscience Research·T Ebendal
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Aug 31, 2002·Microscopy Research and Technique·Takaki MiwaMitsuru Furukawa
Feb 13, 2003·The Journal of Cell Biology·Emma-Jane WilliamsPatrick Doherty
Jun 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Sachin PatelCecilia J Hillard
Oct 8, 2003·Current Drug Targets. CNS and Neurological Disorders·Shivanand P LadElliott J Mufson
Apr 14, 2004·The European Journal of Neuroscience·Leonid G KhaspekovBeat Lutz
Jun 2, 2005·Pharmacology, Biochemistry, and Behavior·M P ViverosSandra E File
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·G GobbiD Piomelli
Jan 24, 2006·Nature Reviews. Neuroscience·Olivier Berton, Eric J Nestler
Feb 14, 2006·British Journal of Pharmacology·Antonio Ramón MartínCatalina Alarcón de la Lastra
Jul 28, 2006·Journal of Psychiatric Research·Charles B Nemeroff
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Oct 20, 2006·Current Opinion in Pharmacology·Eero CastrénTomi Rantamäki
Oct 24, 2006·Current Opinion in Pharmacology·Galit ShaltielHusseini K Manji
Dec 23, 2006·Journal of Endocrinological Investigation·S GruendelC Koebnick
May 19, 2007·Brain, Behavior and Evolution·K W S AshwellC R R Watson
May 23, 2007·Social Psychiatry and Psychiatric Epidemiology·Harald Baumeister, Martin Härter
Jun 26, 2007·Biological Psychiatry·Mounira BanasrRonald S Duman
Jul 21, 2007·Neural Plasticity·María-Paz ViverosMeritxell López-Gallardo
Sep 14, 2007·Annals of Medicine·Keith Q Tanis, Ronald S Duman
Feb 9, 2008·The American Journal of Clinical Nutrition·Iris ErlundAntti Jula
Feb 19, 2008·Current Opinion in Psychiatry·Gill van der WattAleksandar Janca
Apr 19, 2008·IUBMB Life·Luciano Pirola, Sara Fröjdö
Dec 5, 2008·Journal of Medicinal Food·Enguo FanYuhua Bai
Feb 3, 2009·Journal of Neurochemistry·Antonio Rodríguez-GaztelumendiAlvaro Díaz
May 16, 2009·Current Pharmaceutical Design·Francis Rodriguez BambicoGabriella Gobbi
Sep 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James M ConnerMark H Tuszynski
Oct 29, 2009·Alcoholism, Clinical and Experimental Research·Teresa FemeníaJorge Manzanares
Jan 21, 2010·CNS Spectrums·Pierre Blier
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sudhirkumar U YanpallewarVidita A Vaidya
Feb 6, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AbaloM I Martín
Mar 23, 2010·Molecular Neurobiology·Albert Y SunGrace Y Sun
Apr 1, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ying XuWilliam O Ogle

❮ Previous
Next ❯

Citations

Dec 22, 2017·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Parichehr HassanzadehMeshkat Dinarvand
Nov 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Stephanie R WesolowskiJacob E Friedman
Jan 7, 2019·European Journal of Medicinal Chemistry·Priscila Baltazar Gonçalves, Nelilma Correia Romeiro
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mudhi AlAliSwee-Hua Erin Lim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.