The endocannabinoid system in mental disorders: Evidence from human brain studies

Biochemical Pharmacology
Inés Ibarra-LecueLuis F Callado

Abstract

Mental disorders have a high prevalence compared with many other health conditions and are the leading cause of disability worldwide. Several studies performed in the last years support the involvement of the endocannabinoid system in the etiopathogenesis of different mental disorders. The present review will summarize the latest information on the role of the endocannabinoid system in psychiatric disorders, specifically depression, anxiety, and schizophrenia. We will focus on the findings from human brain studies regarding alterations in endocannabinoid levels, cannabinoid receptors and endocannabinoid metabolizing enzymes in patients suffering mental disorders. Studies carried out in humans have consistently demonstrated that the endocannabinoid system is fundamental for emotional homeostasis and cognitive function. Thus, deregulation of the different elements that are part of the endocannabinoid system may contribute to the pathophysiology of several mental disorders. However, the results reported are controversial. In this sense, different alterations in gene and/or protein expression of CB1 receptors have been shown depending on the technical approach used or the brain region studied. Despite the current discrepancies rega...Continue Reading

Citations

May 23, 2019·European Archives of Psychiatry and Clinical Neuroscience·Isabel MaurusPeter Falkai
Sep 6, 2019·Bioanalysis·Momna AslamFlorin Marcel Musteata
Sep 14, 2019·Future Medicinal Chemistry·Francesca GadoClementina Manera
Aug 2, 2019·Current Neuropharmacology·Eric Murillo-RodríguezPablo Torterolo
Jun 27, 2019·Journal of Psychopharmacology·Carolina MuguruzaLuis F Callado
May 13, 2020·Frontiers in Psychiatry·Francisco NavarreteJorge Manzanares
Feb 2, 2019·European Archives of Psychiatry and Clinical Neuroscience·Eva HochOliver Pogarell
Apr 25, 2020·International Journal of Molecular Sciences·Naina Bhatia-Dey, Thomas Heinbockel
Oct 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ferenc ZádorLászló Vécsei

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