The endocannabinoid system in the adipose organ

Reviews in Endocrine & Metabolic Disorders
Kwang-Mook JungDaniele Piomelli

Abstract

The endocannabinoid system is found in most, if not all, mammalian organs and is involved in a variety of physiological functions, ranging from the control of synaptic plasticity in the brain to the modulation of smooth muscle motility in the gastrointestinal tract. This signaling complex consists of G protein-coupled cannabinoid receptors, endogenous ligands for those receptors (endocannabinoids) and enzymes/transporters responsible for the formation and deactivation of these ligands. There are two subtypes of cannabinoid receptors, CB1 and CB2, and two major endocannabinoids, arachidonoylethanolamide (anandamide) and 2-arachidonoyl-sn-glycerol (2-AG), which are produced upon demand through cleavage of distinct phospholipid precursors. All molecular components of the endocannabinoid system are represented in the adipose organ, where endocannabinoid signals are thought to regulate critical homeostatic processes, including adipogenesis, lipogenesis and thermogenesis. Importantly, obesity was found to be associated with excess endocannabinoid activity in visceral fat depots, and the therapeutic potential of normalizing such activity by blocking CB1 receptors has been the focus of substantial preclinical and clinical research. Res...Continue Reading

References

Oct 4, 1995·Biochemical and Biophysical Research Communications·T SugiuraK Waku
Jul 1, 1997·Journal of Neurophysiology·W TwitchellK Mackie
Apr 16, 1999·Nature Neuroscience·A GiuffridaD Piomelli
Nov 9, 2001·Nature·F Rodríguez de FonsecaD Piomelli
May 31, 2002·Pharmacological Reviews·A C HowlettR G Pertwee
Jul 23, 2002·The Journal of Biological Chemistry·Teresa Gómez Del PulgarGuillermo Velasco
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·T P DinhD Piomelli
Jul 5, 2003·Physiological Reviews·Tamas F FreundDaniele Piomelli
Aug 5, 2003·The Journal of Clinical Investigation·Daniela CotaUberto Pagotto
Nov 5, 2003·Nature Reviews. Neuroscience·Daniele Piomelli
Nov 25, 2003·The Journal of Biological Chemistry·Yasuo OkamotoNatsuo Ueda
Mar 2, 2005·Nature Reviews. Molecular Cell Biology·Stefan KraussBradford B Lowell
Apr 28, 2005·Nature Neuroscience·Vincenzo Di Marzo, Isabel Matias
Jun 15, 2005·Annual Review of Biochemistry·Michele K McKinney, Benjamin F Cravatt
Nov 18, 2005·The New England Journal of Medicine·Jean-Pierre DesprésUNKNOWN Rimonabant in Obesity-Lipids Study Group
Jan 6, 2006·Histochemistry and Cell Biology·Régis RocheFranck Festy
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Ken Mackie
Feb 16, 2006·JAMA : the Journal of the American Medical Association·F Xavier Pi-SunyerUNKNOWN RIO-North America Study Group
May 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Isabel MatiasVincenzo Di Marzo
Jun 21, 2006·The Journal of Biological Chemistry·Jesse LoVermeDaniele Piomelli
Dec 5, 2006·Trends in Endocrinology and Metabolism : TEM·Isabel Matias, Vincenzo Di Marzo
Dec 26, 2006·Cellular and Molecular Life Sciences : CMLS·V GasperiM Maccarrone
Jan 17, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M CôtéV Di Marzo
Sep 21, 2007·Nature Reviews. Neuroscience·Daniele PiomelliRao Rapaka
Nov 6, 2007·British Journal of Pharmacology·A M Miller, N Stella
Dec 22, 2007·Chemistry & Biology·Jacqueline L BlankmanBenjamin F Cravatt
Feb 23, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·George Kunos, Douglas Osei-Hyiaman
May 9, 2008·Journal of Neuroendocrinology·C PaganoR Vettor

❮ Previous
Next ❯

Citations

Jun 3, 2021·International Journal of Molecular Sciences·Bruna B BrandãoAtefeh Rabiee
Aug 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tomasz CharytoniukKarolina Konstantynowicz-Nowicka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Gastrointestinal and Liver Physiology
Yunna LeeEunok Im
Current Opinion in Chemical Biology
Alessia LigrestiVincenzo Di Marzo
Nihon rinsho. Japanese journal of clinical medicine
Koh-ichi YuhkiFumitaka Ushikubi
© 2021 Meta ULC. All rights reserved