The endocrinology of male breast cancer

Endocrine-related Cancer
I S Fentiman

Abstract

Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E2) levels from hepatic conversion of androgen. Klinefelter's syndrome (XXY) is associated with a 50-fold increase in incidence of MBC compared with XY males, and this is the most pronounced evidence for testicular malfunction amplifying risk. Delay in presentation means that up to 40% of cases have stage III or stage IV disease at diagnosis. No randomised controlled trials have been reported on endocrine treatment of advanced disease or adjuvant/neoadjuvant therapy following or preceding surgery. Tamoxifen is the most effective endocrine therapy, but side effects can lead to non-compliance in a substantial number of men. Aromatase in...Continue Reading

References

Sep 9, 1978·Lancet·B M CantwellJ L Hayward
Jun 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G G GordonA L Southren
Jul 1, 1975·Clinical Endocrinology·C WangB Hudson
Apr 1, 1992·American Journal of Epidemiology·D B ThomasD F Austin
Feb 1, 1992·British Journal of Cancer·G Ribeiro, R Swindell
Apr 15, 1990·International Journal of Cancer. Journal International Du Cancer·M H Lenfant-PejovicA Auquier
Mar 1, 1973·Archives of Surgery·W L Donegan, C M Perez-Mesa
Dec 1, 1971·Journal of Medical Genetics·D G HarndenA O Langlands
Feb 1, 1971·Annals of Surgery·A F Cortese, G N Cornell
Nov 1, 1983·Clinical Radiology·G G Ribeiro
Jul 31, 1998·Cancer Causes & Control : CCC·A W HsingJ F Fraumeni
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Anders BojesenClaus Højbjerg Gravholt
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Jun 1, 1963·American Journal of Public Health and the Nation's Health·D SCHOTTENFELDH DIAMOND
Dec 1, 1963·British Journal of Cancer·M M EL-GAZAYERLI, A S ABDEL-AZIZ
Mar 6, 2004·Breast Cancer Research and Treatment·William F AndersonSusan S Devesa
Mar 12, 2004·The New England Journal of Medicine·R Charles CoombesUNKNOWN Intergroup Exemestane Study
Jun 29, 2004·Cancer·Sharon H GiordanoGabriel N Hortobagyi
Nov 5, 2005·Cancer·Sharon H GiordanoGabriel N Hortobagyi
Jan 13, 2006·British Journal of Pharmacology·V Craig Jordan
Feb 21, 2006·Lancet·Ian S FentimanGabriel N Hortobagyi
Mar 3, 2007·Breast Cancer Research and Treatment·Khalid Dafaallah AwadelkarimRenato Mariani-Costantini
Oct 9, 2008·Journal of the National Cancer Institute·Louise A BrintonArthur Schatzkin
Mar 31, 2009·Breast Cancer Research and Treatment·Louise A BrintonGloria Gridley
May 16, 2009·Breast Cancer Research : BCR·Yimin GeMing Guo
May 16, 2009·Critical Reviews in Oncology/hematology·B CutuliY Belkacemi
Oct 29, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J DoyenA Thyss
Apr 1, 2011·The Medical Journal of Australia·Amy S HerlihyRobert I McLachlan
Nov 17, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N PemmarajuS H Giordano
Oct 16, 2012·Breast Cancer Research and Treatment·Shouping XuDa Pang
Dec 12, 2012·Breast Cancer Research and Treatment·Holm EggemannSerban-Dan Costa
Apr 3, 2013·European Journal of Pharmacology·Berta SousaFatima Cardoso
Feb 6, 2015·Asian Journal of Andrology·Kathleen Hwang, Martin Miner
Mar 17, 2015·Endocrine·Marlies BekaertJohannes B Ruige
Nov 18, 2015·World Journal of Gastroenterology : WJG·Rosa ZampinoNicola Coppola
Oct 19, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ji Hyung HongIn Sook Woo
Oct 30, 2016·Andrology·R ArthurM Van Hemelrijck

❮ Previous
Next ❯

Citations

Mar 2, 2019·Critical Reviews in Clinical Laboratory Sciences·Stella K Vasiliou, Eleftherios P Diamandis
Oct 6, 2020·Circulation Research·Rana ZahreddineCoralie Fontaine
Apr 9, 2021·Breast Cancer Research and Treatment·Andrew E JohnsonRachel B Jimenez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
H Saito, S Yoshida
Nihon rinsho. Japanese journal of clinical medicine
H Suzuki, H Ito
Ecancermedicalscience
Is Fentiman
© 2022 Meta ULC. All rights reserved