PMID: 6167120Jul 1, 1981Paper

The endocrinology of testicular germinal cell tumors

Acta Endocrinologica
P AigingerG Geyer

Abstract

Oestradiol (Oe2), testosterone (T), lutenizing hormone (LH), follicle stimulating hormone (FSH), beta-human chorionic gonadotrophin (beta-hCG) and alpha-1 foetoprotein (AFP) were measured in blood samples taken from 63 patients with testicular tumours. In patients without tumour recurrence (n=31) AFP, Oe2 and T were within the normal range, beta-hCG was negative, LH levels were marginally elevated and FSH concentrations were significantly elevated. In patients with tumor recurrence (n=32) Oe2 was significantly elevated, whereas the T levels varied considerably and were therefore statistically not different from the patients without tumour recurrence. The beta-hCG positive subgroup of the recurrence group, however, demonstrated significantly elevated T levels. T levels were highest in patients with 51 to 500 U beta-hCG/1. On hand T was normal or even low normal in beta-hCG negative -AFP positive patients. In all subgroups decreasing FSH levels and decreasing LH responses to LRH were among the earliest signs of tumour recurrence. The observations suggest that moderate hCG levels are able to stimulate testicular T production, whereas high levels no longer increase T serum concentrations. Increased conversion rates form steroid pre...Continue Reading

Citations

Jan 1, 1981·International Urology and Nephrology·M SasI Szilágyi
Jan 1, 1987·International Urology and Nephrology·Z Uysal, M Bakkaloğlu
Jul 21, 2011·Journal of Osteoporosis·Daniela MerlottiRanuccio Nuti
Jan 1, 1983·Scandinavian Journal of Urology and Nephrology·J G BerthelsenM Rørth
Apr 18, 2003·Clinical Endocrinology·Willem de RondeFrank H de Jong
Dec 1, 1994·Urology·L C FungG W Gardiner
Mar 1, 2006·Expert Review of Endocrinology & Metabolism·Luigi GennariJohn P Bilezikian
Jan 1, 1988·Journal of Andrology·L LiuB C Nisula
Oct 2, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Cory A Faw, Robert E Brannigan
Mar 1, 1986·Annals of Clinical Biochemistry·A A IsmailM J Wheeler

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