PMID: 862440Jun 1, 1977Paper

The endocrinometabolic effects of beclomethasone dipropionate in asthmatic patients

Chest
J C YernaultG Copinschi

Abstract

The endocrinometabolic effects of the aerosol administration of beclomethasone dipropionate (100 microng four times daily) were evaluated in 20 asthmatic patients (11 corticodependent and nine noncorticodependent) during one month. In the noncorticodependent group, aerosol administration of beclomethasone had no statistically significant effect on the results of the glucose tolerance test and the plasma levels of insulin; there was a slight decrease in basal levels of cortisol, but the response of the cortisol level to administration of ACTH remained quite normal. In corticodependent patients, after substitution of aerosol therapy with beclomethasone for the oral therapy with steroids, the depression of adrenal function disappeared, usually quickly (in less than one month), whereas the abnormalities in the results of the glucose tolerance test persisted. Thus, at the dosage used, beclomethasone dipropionate might have minor systemic endocrinometabolic effects.

References

Feb 3, 1973·British Medical Journal·J C BattenM E Hodson
Jul 1, 1973·British Journal of Diseases of the Chest·A P SmithA J Davey
Apr 1, 1972·British Journal of Diseases of the Chest·Y F Choo-KangI W Grant
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher

Citations

Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D L Maxwell
Feb 1, 1995·The American Journal of Medicine·N A HananiaS Kesten
Mar 4, 2000·Allergy·G PassalacquaH J Malling
Mar 1, 1997·Respirology : Official Journal of the Asian Pacific Society of Respirology·B Zainudin
Sep 1, 1991·The Journal of Allergy and Clinical Immunology·M TurpeinenK Juntunen-Backman
Sep 9, 2017·Endocrine·Bayar QasimHerish Ahmed
Dec 15, 1979·The Medical Journal of Australia·M Horowitz, R B Burnet

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