The endogenous cannabinoid system and its role in nociceptive behavior

Journal of Neurobiology
Benjamin F Cravatt, Aron H Lichtman

Abstract

The analgesic properties of exogenous cannabinoids have been recognized for many years and suggest a regulatory role for the endogenous cannabinoid ("endocannabinoid") system in mammalian nociceptive pathways. The endocannabinoid system includes: (1) at least two families of lipid signaling molecules, the N-acyl ethanolamines (e.g., anandamide) and the monoacylglycerols (e.g., 2-arachidonoyl glycerol); (2) multiple enzymes involved in the biosynthesis and degradation of these lipids, including the integral membrane enzyme fatty acid amide hydrolase; and (3) two G-protein coupled receptors, CB1 and CB2, which are primarily localized to the nervous system and immune system, respectively. Here, we review recent genetic, behavioral, and pharmacological studies that have tested the function of the endocannabinoid system in pain sensation. Collectively, these investigations support a role for endocannabinoids in modulating behavioral responses to acute, inflammatory, and neuropathic pain stimuli.

References

Sep 4, 1997·Nature·R MechoulamZ Vogel
Nov 5, 1997·European Journal of Pharmacology·R S LandsmanH I Yamamura
Apr 16, 1998·Pain·Jennelle Durnett RichardsonKenneth M Hargreaves
Jul 31, 1998·Nature·A CalignanoD Piomelli
Oct 6, 1998·Nature·I D MengH L Fields
Feb 12, 1999·Neurobiology of Disease·B R Martin, A H Lichtman
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·A ZimmerT I Bonner
May 13, 1999·Neuroreport·A S BasileW B Mendelson
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·J M WalkerM C Sañudo-Peña
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·L HanusE Fride
Mar 11, 2000·The European Journal of Neuroscience·O ValverdeB P Roques
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·D L BogerB F Cravatt
May 24, 2000·European Journal of Pharmacology·P Beaulieu1A S Rice
Jun 22, 2000·Molecular and Cellular Neurosciences·W P Farquhar-SmithM R Elphick
Dec 7, 2000·Chemistry and Physics of Lipids·C J Hillard, A Jarrahian
Feb 13, 2001·Progress in Neurobiology·R G Pertwee
Mar 14, 2001·European Journal of Pharmacology·A SieglingJ De Vry
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·N FukushimaJ Chun

❮ Previous
Next ❯

Citations

Jan 23, 2008·Psychopharmacology·Sam A Deadwyler, Robert E Hampson
Sep 2, 2008·Molecular Neurobiology·Angela Fontán-LozanoAngel Manuel Carrión
Jul 27, 2011·Neuroscience Bulletin·Daniel Alonso-AlconadaEnrique Hilario
Aug 5, 2012·Tetrahedron·Spyros P NikasAlexandros Makriyannis
Nov 23, 2007·Biochemistry·Ziqiang GuanChristian R H Raetz
Jun 15, 2007·Journal of Medicinal Chemistry·Christophe HardouinDale L Boger
Apr 7, 2005·Nature Medicine·Krisztina Monory, Beat Lutz
Jan 18, 2006·Cell Death and Differentiation·M T CorasanitiG Bagetta
Nov 23, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paola SarchielliPaolo Calabresi
May 31, 2008·British Journal of Anaesthesia·A Dray
Dec 22, 2010·British Journal of Anaesthesia·C Voscopoulos, M Lema
Jan 27, 2009·The Journal of Pharmacology and Experimental Therapeutics·Joel E SchlosburgAron H Lichtman
Apr 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Pál PacherGeorge Kunos
Apr 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sándor BátkaiPál Pacher
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Mary-Ann Fitzcharles, Yoram Shir
Jun 15, 2007·Arthritis Research & Therapy·Andy Dray, Simon J Read
Aug 2, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ian GilronDwight E Moulin
Jan 31, 2008·Current Oncology·J Myers, N Shetty
Jul 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Simone de Souza NascimentoLucindo José Quintans-Júnior
Oct 19, 2013·The Proceedings of the Nutrition Society·Roger G Pertwee
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Raphael Mechoulam, Dale G Deutsch
Apr 16, 2009·International Review of Psychiatry·Sandra P Welch
Jun 10, 2014·International Reviews of Immunology·Jessica Margaret SidoMitzi Nagarkatti
May 16, 2009·Expert Opinion on Therapeutic Patents·Konstantinos GiannitsasPetros Perimenis
Jul 12, 2005·Expert Opinion on Investigational Drugs·Alyson Fox, Stuart Bevan
May 2, 2008·Expert Opinion on Investigational Drugs·Simon J Read, Andy Dray
Jul 25, 2012·The Journal of Physiology·Ako KatoHanns Ulrich Zeilhofer
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Helena KhaliullinaSuzanne Eaton
Jun 8, 2013·Maturitas·Jacob N Ablin, Dan Buskila
Feb 24, 2010·Life Sciences·Alysia N Lozano-OndouaTodd W Vanderah
Feb 16, 2010·Immunobiology·Lucie Jean-GillesCris S Constantinescu
Aug 18, 2009·Prostaglandins & Other Lipid Mediators·Jeffrey M McCueGregory P Mueller
Sep 3, 2008·European Journal of Pharmacology·Victoria L HallerSandra P Welch
Jul 22, 2008·Rheumatic Diseases Clinics of North America·Andy Dray
Nov 3, 2007·The Journal of Pain : Official Journal of the American Pain Society·Ryan Quinlan SkrabekDaryl Perry
Dec 20, 2007·The Journal of Pain : Official Journal of the American Pain Society·C Richard ChapmanChan Woo Song

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.