The endogenous cardiotonic steroid Marinobufagenin and decline in estimated glomerular filtration rate at follow-up in patients with arterial hypertension

PloS One
Martin H KeppelStefan Pilz

Abstract

Marinobufagenin (MBG) is an endogenous cardiotonic steroid (CTS) that inhibits the Na+/K+-ATPase. Human MBG is significantly increased in end-stage renal disease and immunization against MBG attenuates cardiovascular fibrosis in a rat model of uremic cardiomyopathy. Mineralocorticoid antagonists (MRA) block MBG binding sites and decrease proteinuria in chronic kidney disease (CKD) patients. We therefore aimed to investigate the association of MBG and albuminuria, as a marker of renal damage, as well as MBG and decline of glomerular filtration rate (GFR). The Graz endocrine causes of hypertension (GECOH) study is a single center study of adults routinely referred for screening of endocrine hypertension. Plasma MBG was measured by an enzyme-linked immunoassay, and in a post-hoc analysis, follow-up creatinine levels were obtained. Patients with proteinuria >3.5g/day at baseline were excluded from further evaluation. We measured MBG concentrations in 40 hypertensive subjects and excluded one patient due to pre-existing proteinuria. Plasma MBG was significantly correlated with albuminuria (Spearman ρ = .357; p = .028) and proteinuria (ρ = .336; p = .039). In linear regression analysis, the association remained significant after adju...Continue Reading

References

Apr 5, 2003·Kidney International·Snigdha PriyadarshiJoseph I Shapiro
Dec 12, 2007·Journal of Internal Medicine·P StellaC Zoccali
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S BombackPhilip J Klemmer
Jan 30, 2009·American Journal of Physiology. Renal Physiology·Larisa V FedorovaDeepak Malhotra
Feb 26, 2009·Journal of Evaluation in Clinical Practice·Nathalie ThillyLuc Frimat
Mar 6, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Sankar D NavaneethanGiovanni F M Strippoli
Mar 28, 2009·Pharmacological Reviews·Alexei Y BagrovOlga V Fedorova
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Feb 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Elena V KolmakovaAlexei Y Bagrov
Apr 13, 2011·JAMA : the Journal of the American Medical Association·Navdeep TangriAndrew S Levey
Oct 21, 2011·The Journal of Clinical Endocrinology and Metabolism·Stefan PilzAndreas Tomaschitz
Mar 21, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Grzegorz PiechaMarie-Luise Gross-Weissmann
Apr 3, 2012·Renal Failure·Terry King-Wing Ma, Cheuk-Chun Szeto
Sep 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alireza EsteghamatiManouchehr Nakhjavani
May 3, 2014·Clinical and Experimental Hypertension : CHE·Andreas TomaschitzStefan Pilz
Jun 13, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marco SimoniniUNKNOWN CABG Genomics Investigators
Oct 16, 2014·The Cochrane Database of Systematic Reviews·Hong Mei WuGuan J Liu
Nov 6, 2014·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·T N ShelykhB V Krylov
Apr 25, 2015·Advances in Chronic Kidney Disease·John M Hamlyn, Paolo Manunta
Jul 3, 2015·Journal of Hypertension·Olga V FedorovaAlexei Y Bagrov
Apr 28, 2016·Postȩpy higieny i medycyny doświadczalnej·Aneta PaczulaGrzegorz Piecha

❮ Previous
Next ❯

Citations

Jun 3, 2021·Toxins·Jiří BejčekSilvie Rimpelová

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunoassay

Software Mentioned

SAS
GECOH

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.