The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module

Cancer Research
Ke ChenRichard G Pestell

Abstract

Prostate cancer is the second leading form of cancer-related death in men. In a subset of prostate cancer patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant prostate cancer (CRPC). IL8 and IL6 are produced by prostate epithelial cells and promote prostate cancer cell invasion; however, the mechanisms restraining prostate epithelial cell cytokine secretion are poorly understood. Herein, the cell-fate determinant factor DACH1 inhibited CRPC tumor growth in mice. Using Dach1(fl/fl)/Probasin-Cre bitransgenic mice, we show IL8 and IL6 secretion was altered by approximately 1,000-fold by endogenous Dach1. Endogenous Dach1 is shown to serve as a key endogenous restraint to prostate epithelial cell growth and restrains migration via CXCL signaling. DACH1 inhibited expression, transcription, and secretion of the CXCL genes (IL8 and IL6) by binding to their promoter regulatory regions in chromatin. DACH1 is thus a newly defined determinant of benign and malignant prostate epithelium cellular growth, migration, and cytokine abundance in vivo.

References

Aug 26, 1999·In Vitro Cellular & Developmental Biology. Animal·R M SramkoskiJ W Jacobberger
Nov 21, 2002·The Journal of Biological Chemistry·Guoqing LiaoJ Don Chen
Jun 13, 2003·Molecular Biology of the Cell·Peter NeumeisterRichard G Pestell
Oct 4, 2003·The Journal of Biological Chemistry·Kongming WuRichard G Pestell
Apr 15, 2004·Endocrine Reviews·Cynthia A Heinlein, Chawnshang Chang
Apr 20, 2005·Journal of Cellular Biochemistry·Zoran CuligAlfred Hobisch
Nov 3, 2005·Nature Clinical Practice. Oncology·Hiroshi MiyamotoChawnshang Chang
May 18, 2006·Molecular and Cellular Biology·Zhiping LiRichard G Pestell
Aug 2, 2006·Genome Biology·Jennifer Jemc, Ilaria Rebay
Aug 23, 2006·Molecular and Cellular Biology·Maofu FuRichard G Pestell
Sep 19, 2006·Molecular and Cellular Biology·Kongming WuRichard G Pestell
Apr 17, 2007·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Stephan H FlüchterChristoph Gamper
Apr 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xiaoming JuRichard G Pestell
May 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kongming WuRichard G Pestell
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J J Waugh, Catherine Wilson
Apr 8, 2009·The American Journal of Pathology·Manran LiuRichard G Pestell
Jun 9, 2009·Cancer Biology & Therapy·Fangfang NanChenguang Wang
Nov 10, 2009·Trends in Endocrinology and Metabolism : TEM·Vladimir M PopovRichard G Pestell
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jie ZhouRichard G Pestell
Jun 29, 2010·Cancer Cell·Barry S TaylorWilliam L Gerald
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Sep 3, 2010·Journal of Cancer Science & Therapy·Rajendra K SinghBal L Lokeshwar
Oct 13, 2010·The Journal of Biological Chemistry·Kongming WuRichard G Pestell
Oct 14, 2010·Cancer Research·Zhiping LiRichard G Pestell
Dec 9, 2010·The Journal of Biological Chemistry·Chao WangJoseph L Napoli
Jul 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Akira WatanabeHiroyuki Aburatani
Feb 7, 2012·The Journal of Clinical Investigation·Mathew C CasimiroRichard G Pestell
Mar 16, 2013·Cancer Research·Ke ChenRichard G Pestell
Apr 6, 2013·Critical Reviews in Eukaryotic Gene Expression·Nicole SalazarBal L Lokeshwar
Jul 17, 2013·Nature Reviews. Urology·Pavel Sluka, Ian D Davis
Mar 19, 2014·Endocrine-related Cancer·Christine HelsenFrank Claessens

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Citations

Sep 1, 2016·Cytokine & Growth Factor Reviews·Qian LiuKongming Wu
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qian LiuKongming Wu
Apr 11, 2018·Journal of Hematology & Oncology·Qian LiuKongming Wu
Nov 1, 2018·American Journal of Physiology. Renal Physiology·Masahiro OkabeTaiji Matsusaka
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Wan-Fu WuJan-Åke Gustafsson
Sep 29, 2018·Head & Face Medicine·Jiarui ZhangMing Liu
May 18, 2021·The Journal of Clinical Investigation·Tomohito DokeKatalin Susztak

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