PMID: 9416782Jan 1, 1997Paper

The endogenous mu-opioid agonists, endomorphin 1 and 2, have vasodilator activity in the hindquarters vascular bed of the rat

Life Sciences
H C ChampionP J Kadowitz

Abstract

Endomorphin 1 and endomorphin 2 are newly-discovered endogenous ligands for the mu-opioid receptor. In the present study, responses to intra-arterial injections of endomorphin 1 and 2 were investigated in the hindquarters vascular bed of the rat. Under constant-flow conditions, endomorphin 1 and 2 induced dose-dependent decreases in hindquarters perfusion pressure when injected in doses of 3-100 nmol into the hindquarters perfusion circuit. Vasodilator responses to endomorphin 1 and 2 and met-enkephalin were attenuated by the opioid receptor antagonist naloxone (2 mg/kg i.v.) at a time when vasodilator responses to isoproterenol were not altered. In terms of relative vasodilator activity, endomorphin 1 and 2 were similar to ATP, 100-fold less potent than isoproterenol, and 10,000-fold less potent than acetylcholine. These data demonstrate that endomorphin 1 and 2 have significant naloxone-sensitive vasodilator activity in the hindquarters vascular bed of the rat.

Citations

Mar 17, 1999·European Journal of Pharmacology·B PrzewłockaR Przewłocki
Apr 27, 2000·Journal of Chemical Neuroanatomy·T L Pierce, M W Wessendorf
Nov 18, 2000·British Journal of Pharmacology·C HarrisonD G Lambert
Mar 11, 2000·The European Journal of Neuroscience·K MonoryA Borsodi
Feb 17, 2000·Annals of the New York Academy of Sciences·H C ChampionP J Kadowitz
May 18, 2000·Journal of Neuroimmunology·D S JessopF M De Bree
Nov 9, 2007·Peptides·Weihong Pan, Abba J Kastin
Mar 3, 2007·Pharmacological Reviews·Jakub FichnaJean-Claude Do Rego
Oct 10, 2002·Chemical & Pharmaceutical Bulletin·Akihiro AmboYusuke Sasaki

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