The endoplasmic reticulum: one continuous or several separate Ca(2+) stores?

Trends in Neurosciences
Ole H PetersenM K Park

Abstract

The Ca2+ store and sink in the endoplasmic reticulum (ER) is important for Ca2+ signal integration and for conveyance of information in spatial and temporal domains. Textbooks regard the ER as one continuous network, but biochemical and biophysical studies revealed apparently discrete ER Ca2+ stores. Recent direct studies of ER lumenal Ca2+ movements show that this organelle system is one continuous Ca2+ store, which can function as a Ca2+ tunnel. The concept of a fully connected ER network is entirely compatible with evidence indicating that the distribution of Ca2+ -release channels in the ER membrane is discontinuous with clustering in certain localities.

References

Dec 1, 1988·The Journal of Cell Biology·S HashimotoJ Meldolesi
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P VolpeD P Lew
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·M TerasakiT S Reese
Jan 1, 1994·Annual Review of Physiology·O H PetersenH Kasai
Sep 1, 1993·The Journal of Physiology·Z Zhou, E Neher
Mar 1, 1993·The Journal of Physiology·P BelanA Tepikin
Nov 1, 1996·The Journal of Physiology·L Fierro, I Llano
Nov 14, 1997·Physiological Reviews·A B Parekh, R Penner
Feb 11, 1998·Physiological Reviews·A VerkhratskyH Kettenmann
Feb 17, 1998·Trends in Neurosciences·A Verkhratsky, E C Toescu
May 28, 1998·Cell Calcium·O H PetersenA V Tepikin
Aug 11, 1998·Neuron·M J Berridge
Dec 9, 1998·Current Biology : CB·J V GerasimenkoO V Gerasimenko
Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·O H PetersenA V Tepikin
Oct 26, 1999·Trends in Neurosciences·O H Petersen, J M Cancela
Apr 27, 2000·Trends in Biochemical Sciences·G A Rutter, R Rizzuto
May 16, 2000·The Journal of Physiology·L D Pozzo-MillerS B Andrews
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·A B Parekh
Dec 15, 2000·Cell Calcium·T PozzanR Rizzuto

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Citations

Jul 6, 2007·Pflügers Archiv : European journal of physiology·Wolfgang F GraierRoland Malli
Mar 20, 2009·Pflügers Archiv : European journal of physiology·Vicky C JonesOwen T Jones
Apr 23, 2010·Pflügers Archiv : European journal of physiology·Rudgar NeussertOlaf Strauss
Jun 2, 2012·Pflügers Archiv : European journal of physiology·Oleg V Gerasimenko, Julia V Gerasimenko
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alexei VerkhratskyJose Julio Rodriguez
Aug 2, 2002·European Journal of Pharmacology·Alexej Verkhratsky, Ole H Petersen
Jan 25, 2003·Cell Calcium·A Verkhratsky
Jan 25, 2003·Cell Calcium·O V GerasimenkoO H Petersen
Jan 22, 2003·Journal of Neuroscience Methods·Natasha Solovyova, Alexei Verkhratsky
Mar 27, 2003·Neuroscience Research·Miho Sugioka, Masayuki Yamashita
Jun 12, 2009·The Journal of Biological Chemistry·Heidi K BaumgartnerOleg V Gerasimenko
Mar 12, 2009·The Journal of Biological Chemistry·Omar A RamírezAndrés Couve
Mar 29, 2011·Cold Spring Harbor Perspectives in Biology·Djalila MekahliLudwig Missiaen
Jun 22, 2006·Acta Pharmacologica Sinica·He-ping ChengAlexei Verkhratsky
Jun 17, 2006·Acta Physiologica·A Verkhratsky
Jul 29, 2004·Science's STKE : Signal Transduction Knowledge Environment·Donald L Gill, Randen L Patterson
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Paul O HassaMichael O Hottiger
Sep 14, 2007·Annual Review of Physiology·Ole H Petersen, Alexei V Tepikin
Dec 23, 2011·American Journal of Physiology. Renal Physiology·Francesca Di SoleVictor Babich
Mar 29, 2008·PLoS Computational Biology·Isaac ShemerSten Grillner
May 22, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jyoti C PatelMargaret E Rice
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M K ParkO H Petersen
Jul 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·David N CriddleRobert Sutton
Feb 11, 2010·Neurochemistry International·Alexei Verkhratsky
Apr 17, 2007·Trends in Biochemical Sciences·Patrick G Hogan, Anjana Rao
Jul 31, 2013·The Journal of Physiology·Julia V GerasimenkoOle H Petersen
Sep 18, 2004·Trends in Neurosciences·Emil C ToescuPhilip W Landfield
Aug 4, 2005·Cell Calcium·Denis BurdakovAlexei Verkhratsky
Dec 15, 2010·Biochimica Et Biophysica Acta·Jean-Paul DecuypereJan B Parys
Dec 2, 2010·Biochimica Et Biophysica Acta·Vladimir ParpuraAlexei Verkhratsky

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