The endoplasmic reticulum-related events in S-nitrosoglutathione-induced neurotoxicity in cerebellar granule cells

Brain Research
Jie HeChang Chen

Abstract

Nitric oxide (NO)-induced neurotoxicities are involved in the pathogenesis of several neurodegenerative disorders featured by misfolded proteins. However, the details remain to be investigated. In the present work, we focus on the study of some endoplasmic reticulum-related events in S-nitrosoglutathione (GSNO)-induced neurotoxicity in cerebellar granule cells (CGCs) and we demonstrated that: (1) GSNO caused sustained elevation of intracellular calcium; (2) This calcium elevation resulted partially from the depletion of endoplasmic reticulum (ER) calcium stores; (3) There was ER stress which was indicated by the incomplete splicing of X-box binding protein (XBP-1) mRNA by 8-polysialyltransferase (Pst1); (4) GSNO upregulated the expression of the proapoptotic growth arrest and DNA damage-inducible gene (Gadd153) and caused the depletion of intracellular glutathione (GSH) pools. At the same time, GSNO downregulated the expression of the antiapoptotic gene Sarco/endoplasmic reticulum calcium-ATPase (SERCA2b) in parallel with the downregulation of the antiapoptotic ER chaperones-glucose-regulated protein genes (Grp78 and Grp94). These effects indicate that ER is one of the NO targets in GSNO-induced neurotoxicity in cerebellar gran...Continue Reading

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Citations

Dec 1, 2005·Journal of Biological Physics·Nadiya A Brazhe UlyanovaGeorgy V Maksimov
Aug 25, 2010·Neurochemical Research·Hsueh-Meei HuangGary E Gibson
Jul 6, 2011·Journal of Molecular Neuroscience : MN·Ceri E OldreiveGayle Helane Doherty
Apr 2, 2008·Antioxidants & Redox Signaling·Cecilia Hidalgo, Paulina Donoso
Nov 13, 2014·Canadian Journal of Physiology and Pharmacology·Caroline SodjaMahmud Bani-Yaghoub
Mar 18, 2008·Journal of Neuropathology and Experimental Neurology·Aoife Ní MháilleUna FitzGerald
Jun 16, 2010·Nitric Oxide : Biology and Chemistry·Guy C Brown
Apr 15, 2008·Neurochemistry International·Ceri E OldreiveGayle H Doherty
Mar 9, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Paula CunneaUna FitzGerald
Dec 14, 2006·ACS Chemical Biology·Moran BenharJonathan S Stamler
Oct 12, 2010·Journal of Proteome Research·Yi-Ju ChenYu-Ju Chen

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