The endothelin axis in uterine leiomyomas: new insights

Biology of Reproduction
Zahra Tanfin, M Breuiller-Fouché

Abstract

The endothelin axis, comprising endothelin-1 (ET-1) and its receptors (ETA and ETB), is involved in the pathophysiology of different human tumors. Here we review conventional approaches and gene expression profiling indicating the association of ET-1 and its cognate receptors with human and rat leiomyomas, the most common benign tumors of myometrium. Specifically, ET-1/ETA interactions affect human and rat leiomyoma cell proliferation through protein kinase C and mitogen-activated protein kinase-dependent signaling pathways. Recent experiments demonstrate that the ET-1 axis exerts a potent antiapoptotic effect involving sphingolipid metabolism and prostaglandin-endoperoxide synthase 2/prostaglandin system in the rat Eker leiomyoma tumor-derived ELT3 cell line. Evidence supports that steroid hormones, growth factors, and extracellular matrix are key regulators of the leiomyoma growth. Interestingly, the ET-1 axis is under steroid hormones and can cooperate with these growth factors. Therefore, ET-1 alone or in association with these factors could contribute to the complex regulation of uterine tumor growth, such as proliferation, survival, and extracellular matrix production. This review summarizes current knowledge and emerging...Continue Reading

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Citations

Aug 21, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gordon A G McKenzieDaniel W Lambert
Aug 21, 2014·Reproductive Sciences·Kedra WallaceBabbette LaMarca
Oct 12, 2018·Clinical Science·Kedra WallaceBabbette LaMarca
May 21, 2019·Journal of Cellular Biochemistry·Aynaz MihanfarMohammad Nouri

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Methods Mentioned

BETA
hysterectomy
transgenic

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