The endothelium as the common denominator in malignant hypertension and thrombotic microangiopathy

Journal of the American Society of Hypertension : JASH
Roy O MathewArif Asif

Abstract

The endothelium plays a pivotal role in vascular biology. The endothelium is the primary site of injury in thrombotic microangiopathies including malignant hypertension. Endothelial injury in thrombotic microangiopathies is the result of increased shear stress, toxins, and/or dysregulated complement activation. Endothelial injury can lead to microvascular thrombosis resulting in ischemia and organ dysfunction, the clinical hallmarks of thrombotic microangiopathies. Currently, available therapies target the underlying mechanisms that lead to endothelial injury in these conditions. Ongoing investigations aim at identifying drugs that protect the endothelium.

References

May 1, 1990·Hypertension·T F Lüscher
Aug 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W ProesmansP Lijnen
Jun 30, 2000·The New England Journal of Medicine·L B Zimmerhackl
Jul 12, 2001·Seminars in Thrombosis and Hemostasis·C M Taylor
Feb 8, 2003·Hypertension·Richard A PrestonYeon S Ahn
Jun 23, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yugo Shibagaki, Toshiro Fujita
Jan 3, 2006·Seminars in Thrombosis and Hemostasis·Eric Chun-Yet Lian
Mar 12, 2008·Hypertension·Bert-Jan H van den BornGert A van Montfrans
Nov 8, 2008·Cell and Tissue Research·Gilles N ChironiAlain Tedgui
May 12, 2009·The Medical Clinics of North America·Camila ManriqueJames R Sowers
Dec 17, 2009·Clinical Reviews in Allergy & Immunology·Luc MouthonLoïc Guillevin
Dec 25, 2009·Blood·Johanna A Kremer HovingaJames N George
Oct 20, 2010·British Journal of Haematology·Luca A LottaFlora Peyvandi
Mar 27, 2012·Clinical and Experimental Pharmacology & Physiology·Tasuku NagasawaJohn D Imig
Jul 18, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas BarbourPeter Hughes
Dec 12, 2012·Frontiers in Physiology·Bruno R SilvaLusiane M Bendhack
Apr 23, 2013·American Journal of Hematology·Shruti ChaturvediKeith R McCrae
Aug 19, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Yan ZhengRobert W Maitta
Sep 12, 2014·International Journal of Nephrology·Hassan Izzedine
Nov 6, 2014·The New England Journal of Medicine·James N George, Carla M Nester
Dec 17, 2014·Clinical Kidney Journal·Chike NzerueMarquetta Faulkner
Mar 15, 2015·Circulation Research·Luuk Te RietA H Jan Danser
May 1, 2015·Clinical Science·Mamoru SatohMotoyuki Nakamura
Jul 18, 2015·Journal of the American Society of Nephrology : JASN·An S De VrieseFernando C Fervenza
Sep 28, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Carmine PecoraroGiuseppe Remuzzi

❮ Previous
Next ❯

Citations

Mar 1, 2017·Lancet·Fadi FakhouriChantal Loirat
Apr 19, 2017·Blood·T Sakari Jokiranta
Nov 8, 2018·Clinical Hemorheology and Microcirculation·Juliane RiegerJohanna Plendl
Nov 7, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Marta PalomoMaribel Diaz-Ricart
Feb 10, 2018·Clinical Kidney Journal·Adriana DejmanAli Nayer
Oct 12, 2017·Frontiers in Medicine·Céline LouisYannick D Muller
Apr 3, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jamie S ChuaIngeborg M Bajema
Mar 25, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Teresa CaveroManuel Praga
Jan 25, 2020·Toxins·Adrien JosephAlexandre Hertig
Jul 11, 2020·Journal of Hypertension·Philippe GosseAntoine Cremer
Jun 4, 2020·Current Opinion in Cardiology·Muhannad AlqudsiJuan Carlos Q Velez
May 16, 2017·Kidney International·Steven Van Laecke, Wim Van Biesen
Oct 30, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ludwig HaydockPaul Isenring

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Related Papers

British Journal of Haematology
Shuju FengVahid Afshar-Kharghan
American Journal of Clinical Pathology
V Pardo, A Aburano
Mayo Clinic Proceedings
Brian S Rifkin, Ursula C Brewster
Nefrología : publicación oficial de la Sociedad Española Nefrologia
M P Ruiz-TorresG Remuzzi
© 2022 Meta ULC. All rights reserved