The endothelium in acute lung injury/acute respiratory distress syndrome

Current Opinion in Critical Care
Nikolaos A Maniatis, Stylianos E Orfanos

Abstract

Since pulmonary edema from increased endothelial permeability is the hallmark of acute lung injury, a frequently encountered entity in critical care medicine, the study of endothelial responses in this setting is crucial to the development of effective endothelial-targeted treatments. From the enormous amount of research in the field of endothelial pathophysiology, we have focused on work delineating endothelial alterations elicited by noxious stimuli implicated in acute lung injury. The bulk of the material covered deals with molecular and cellular aspects of the pathogenesis, reflecting current trends in the published literature. We initially discuss pathways of endothelial dysfunction in acute lung injury and then cover the mechanisms of endothelial protection. Several experimental treatments in animal models are presented, which aid in the understanding of the disease pathogenesis and provide evidence for potentially useful therapies. Mechanistic studies have delivered several interventions, which are effective in preventing and treating experimental acute lung injury and have thus provided objectives for translational studies. Some of these modalities may evolve into clinically useful tools in the treatment of this devasta...Continue Reading

References

Sep 25, 2001·Journal of Applied Physiology·S M Dudek, J G Garcia
Jul 20, 2004·Intensive Care Medicine·S E OrfanosC Roussos
Dec 24, 2005·Physiological Reviews·Dolly Mehta, Asrar B Malik
Apr 25, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Raja-Elie E AbdulnourPaul M Hassoun
Jun 3, 2006·American Journal of Respiratory and Critical Care Medicine·Kazuo YoshidaClaire M Doerschuk
Jun 20, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Janie Orrington-MyersAsrar B Malik
Jul 4, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sandra PerkowskiMelpo Christofidou-Solomidou
Jul 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anette M KunigSteven H Abman
Jul 28, 2006·Pediatric Pulmonology·Paul KinniryMelpo Christofidou-Solomidou
Aug 1, 2006·The Journal of Clinical Investigation·Kaushik ParthasarathiJahar Bhattacharya
Aug 8, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniel J AngeliniSimeon E Goldblum
Aug 19, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sho YoshimuraMitsuhiro Yokoyama
Aug 19, 2006·Respiratory Physiology & Neurobiology·A KaminskiC Stamm
Aug 24, 2006·Journal of Vascular Research·Rainer KiefmannAlwin Eduard Goetz
Sep 6, 2006·Circulation·Douglas B Cowan, Francis X McGowan
Sep 7, 2006·The Journal of Clinical Investigation·You-Yang ZhaoAsrar B Malik
Sep 9, 2006·Vascular Pharmacology·Anastasia KotanidouStylianos E Orfanos
Sep 15, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xuchen ZhangPatty J Lee
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sean GarreanAsrar B Malik
Sep 30, 2006·American Journal of Respiratory Cell and Molecular Biology·Srinivas PapaiahgariSekhar P Reddy
Oct 3, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sadiqa K Quadri, Jahar Bhattacharya
Oct 3, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Natalia V BogatchevaAlexander D Verin
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher DalyJohn S Rudge
Oct 13, 2006·European Journal of Clinical Investigation·R FlaishonA A Weinbroum
Nov 3, 2006·American Journal of Respiratory Cell and Molecular Biology·George SuJean-François Pittet
Nov 4, 2006·American Journal of Respiratory and Critical Care Medicine·Dana E McClintockUNKNOWN National Heart, Lung, and Blood Institute ARDS Network
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyoung S KimVijay K Kalra
Nov 7, 2006·Nature Medicine·Vineet BhandariJack A Elias
Nov 18, 2006·Critical Care Medicine·Stylianos E OrfanosCharis Roussos
Dec 5, 2006·The Journal of Clinical Investigation·Alexander ZarbockKlaus Ley
Dec 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna A BirukovaKonstantin G Birukov
Jan 16, 2007·Intensive Care Medicine·Florence AderBenoit P Guery
Jan 27, 2007·The American Journal of Pathology·Hantamalala Ralay RanaivoRamaroson Andriantsitohaina
Feb 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonathan M SinerPatty J Lee

❮ Previous
Next ❯

Citations

Oct 13, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Susanne Herber-JonatAndreas Schulze
Mar 10, 2009·Intensive Care Medicine·Li SuDavid C Christiani
Sep 19, 2009·American Journal of Respiratory and Critical Care Medicine·Ulrich MattSylvia Knapp
Jun 9, 2012·American Journal of Respiratory Cell and Molecular Biology·Famke AeffnerIan C Davis
Oct 3, 2008·Critical Care : the Official Journal of the Critical Care Forum·Carsten P Schepp, Jörg Reutershan
Nov 5, 2011·Proceedings of the American Thoracic Society·Arshad Rahman, Fabeha Fazal
May 21, 2013·Antiviral Research·Susan M ArmstrongWarren L Lee
Mar 7, 2014·Cell and Tissue Research·Lucie Duluc, Beata Wojciak-Stothard
Jul 26, 2011·Mediators of Inflammation·Ying-Gang ZhuJin-Fu Xu
May 15, 2012·Cellular and Molecular Life Sciences : CMLS·Stéphanie CarnesecchiConstance Barazzone-Argiroffo
Mar 1, 2009·Expert Opinion on Drug Discovery·Alexander D CornetAb Johan Groeneveld
Sep 18, 2012·Vascular Pharmacology·Elisabeth M Storck, Beata Wojciak-Stothard
Jan 23, 2016·The Journal of Allergy and Clinical Immunology·Katharina JandlAkos Heinemann
Feb 15, 2011·The Journal of Surgical Research·Rachel J Santora, Heitham T Hassoun
Aug 17, 2010·Respiratory Physiology & Neurobiology·Mônica C M ChaoPatricia R M Rocco
Feb 11, 2010·Microvascular Research·Jörg KaufmannAnsgar Santel
Aug 30, 2008·Vascular Pharmacology·Nikolaos A ManiatisStylianos E Orfanos
May 31, 2011·Experimental Physiology·Shuxin LinJerry Yu
Aug 2, 2015·Trends in Molecular Medicine·Yu FujitaTakahiro Ochiya
Nov 12, 2013·The American Journal of Pathology·Mark J MondrinosLaurie E Kilpatrick
Jul 6, 2014·American Journal of Respiratory Cell and Molecular Biology·Fanyong MengAnna A Birukova
Oct 4, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Eleftheria LetsiouSteven M Dudek
Nov 1, 2016·Cell and Tissue Research·Sean E GillRuud A W Veldhuizen
Mar 13, 2014·Pulmonary Circulation·Dan N PredescuSanda A Predescu
Jul 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aleksandra LeligdowiczMichael A Matthay
Jan 4, 2019·QJM : Monthly Journal of the Association of Physicians·A PeretzA Blum
Mar 29, 2019·International Journal of Molecular Sciences·Qingliang YangLaurie E Kilpatrick
Jan 17, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laura C PriceStephen John Wort
Jul 4, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Heather MendenVenkatesh Sampath
Dec 12, 2012·Current Opinion in Critical Care·Radu F Neamu, Greg S Martin
Apr 11, 2013·Shock·Mark J MondrinosLaurie E Kilpatrick
Jul 5, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lincoln S SmithThomas R Martin
Jul 10, 2013·Anesthesia and Analgesia·Stephen R CollinsRandal O Dull

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.