PMID: 11899159Mar 20, 2002Paper

The endothelium in clinical cardiac transplantation

The Annals of Thoracic Surgery
S C StoicaS R Large

Abstract

Cardiac transplantation is the most successful therapy for refractory heart failure, but clinical transplantation is still confronted with the problems of acute rejection and acute pump failure. The limiting factor in achieving prolonged survival remains cardiac allograft vasculopathy. In recent years it has become apparent that from brain death onward, the cardiac endothelium plays a key role in these acute and chronic events. Brain death is associated with an inflammatory response that primes the endothelium for cumulative injury during the subsequent stages of ischemic cold storage, reperfusion and allorecognition. As a structural and functional interface, the endothelium is the site at which inflammatory cells move from the bloodstream through the vessel wall into the parenchyma. The endothelium interacts with the complement system, the coagulation and inflammatory cascades, circulating leukocytes, the immune system, the smooth muscle in the vessel wall, and the surrounding matrix and cardiomyocytes. A better understanding of its many roles may lead to expansion of our therapeutic possibilities and better outcomes overall. This article reviews the possible roles of the endothelium in relation to cardiac transplantation, and...Continue Reading

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Citations

May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Serban C StoicaStephen R Large
Jul 5, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R Mehra
Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Serban C StoicaStephen R Large
Apr 5, 2007·Nature Protocols·Tomomi HasegawaDavid J Pinsky
Jan 7, 2005·Seminars in Thoracic and Cardiovascular Surgery·Katherine Lietz, Leslie W Miller
Jan 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I A BoladN R Banner
Nov 28, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Martine DesroisMonique Bernard
Mar 17, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Sebastian EcklStephan M Ensminger
Sep 24, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Edward D Verrier
Nov 18, 2006·Expert Opinion on Pharmacotherapy·Javier SegoviaLuis Alonso-Pulpón
Oct 7, 2004·The Annals of Thoracic Surgery·Robert S PostonBartley P Griffith
May 9, 2006·The Journal of Thoracic and Cardiovascular Surgery·Silke AbeleStephan M Ensminger
Sep 24, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul HerijgersWillem Flameng
Mar 28, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Serban C StoicaJayan Parameshwar
Jul 27, 2007·Free Radical Research·Jean-Christophe CharniotJean-Yves Artigou
Feb 12, 2014·Sensors·Dainius SimelevičiusJulija Razumienė
Feb 20, 2020·Clinical Transplantation·Victoria JernrydJohan Nilsson

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