The enduring legacy of Koji Nakanishi's research on bioorganic chemistry and natural products. Part 1: Isolation, structure determination and mode of action

Chirality
George A EllestadNina Berova

Abstract

In this brief review on Koji Nakanishi's remarkable career in natural products chemistry, we have highlighted a number of his accomplishments that illustrate the broad diversity of his interests. These include the isolation, structure determination, and biological mechanism of action of many natural products including the triterpenoid pristimerin; the diterpenoid ginkgolides; insect and crustacean molting hormones; phytoalexins; the toxic red tide principle brevetoxin; the vanadium tunicate pigments; philanthotoxin from killer wasps; antisickling agents; mitomycin DNA adducts; insect antifeedants; a mitotic hormone, the small molecule fish attractants from the sea anemone; new isolation and purification technologies; molecular chemistry of vision; age-related macular degeneration; and the development of the exciton circular dichroism (CD) chirality method for microscale determination of absolute configuration of natural products and chirality of other chiral molecules and supramolecular assembly.

References

Apr 1, 1979·Photochemistry and Photobiology·K NakanishiB Honig
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D W CorsonK Nakanishi
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A T EldefrawiP N Usherwood
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M TomaszG L Verdine
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C A ParishJ Sparrow
Dec 22, 1999·Chirality·J GuoN Berova
Jun 24, 2000·Science·B BorhanK Nakanishi
Jun 20, 2002·Journal of the American Chemical Society·Yukari FujimotoKoji Nakanishi
Feb 7, 2003·Journal of Medicinal Chemistry·Stine Byskov VogensenKoji Nakanishi
Aug 21, 2003·Organic & Biomolecular Chemistry·Nathan FishkinKoji Nakanishi
Sep 25, 2003·The Journal of Biological Chemistry·Lidija IvicKristian Strømgaard
Mar 24, 2004·Angewandte Chemie·Kristian Strømgaard, Koji Nakanishi
Jun 30, 2005·Journal of the American Chemical Society·Katsunori TanakaNina Berova
Jul 2, 2005·Bioorganic & Medicinal Chemistry·Koji Nakanishi
Jul 30, 2005·Bioorganic & Medicinal Chemistry·Egidio GiorgioNina Berova
Oct 14, 2005·Angewandte Chemie·Ilyas WashingtonKoji Nakanishi
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y NayaK Nakanishi
Apr 19, 2008·Journal of the American Chemical Society·Gennaro PescitelliRobert W Woody
Jan 21, 2010·Chemical Communications : Chem Comm·Toyonobu UsukiGeorge A Ellestad
Nov 18, 2011·Journal of the American Chemical Society·Lada KlaićRichard B Silverman
May 15, 2012·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Manickam Sugumaran, William E Robinson
Jan 26, 2013·Journal of Natural Products·Dharati JoshiArie Zask
Oct 16, 2016·Chemical Biology & Drug Design·Akira KawamuraKoji Nakanishi
Jul 30, 2019·Frontiers in Pharmacology·Jia-Jun LiJian-Ye Zhang

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