The enemy within: keeping self-reactive T cells at bay in the periphery

Nature Reviews. Immunology
Lucy S K Walker, Abul K Abbas

Abstract

The remarkable capacity of the mammalian immune system to coordinate deadly attacks against numerous invading pathogens, yet turn a blind eye to self-tissues continues to fascinate immunologists. It has been clear for some time that immune cells capable of recognizing self-proteins exist in normal individuals without seemingly causing harm. The 'peripheral tolerance' mechanisms that keep these cells in check are the focus of intense research, not least because defects in these pathways might cause autoimmune diseases. In this review, new developments in our understanding of peripheral tolerance are discussed.

References

Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Jan 12, 1996·Science·R M Zinkernagel
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·I AndréD Mathis
Jun 1, 1996·The Journal of Experimental Medicine·T L WalunasJ A Bluestone
Aug 1, 1996·The Journal of Experimental Medicine·M AsanoS Sakaguchi
Dec 1, 1996·European Journal of Immunology·J M GombertJ F Bach
Sep 1, 1996·The Journal of Experimental Medicine·C KurtsH Kosaka
Jul 14, 1999·Immunity·D A HildemanP C Marrack
Aug 24, 1999·European Journal of Immunology·H S HiemstraJ W Drijfhout

❮ Previous
Next ❯

Citations

Feb 19, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Claudia Danzer, Jochen Mattner
Dec 18, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Varuna R AluvihareAlexander G Betz
Feb 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nicola J MonkStipo Jurcevic
Sep 15, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lequn Li, Vassiliki A Boussiotis
Sep 21, 2013·Diabetologia·Joachim StørlingFlemming Pociot
May 12, 2005·Cancer Immunology, Immunotherapy : CII·Johannes ScheteligMartin Bornhäuser
Nov 23, 2010·Cancer Immunology, Immunotherapy : CII·Huanfa YiXiang-Yang Wang
Dec 29, 2005·Journal of Clinical Immunology·Peter DubskyA Karolina Palucka
Nov 12, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joseph J SabatinoBrian D Evavold
Aug 21, 2010·Immunologic Research·Dimitrios N VatakisJerome A Zack
Aug 12, 2009·Hepatology International·Hui-Hui TanWan-Cheng Chow
Jan 30, 2004·Cytokine & Growth Factor Reviews·Simone MocellinMario Lise
Dec 10, 2003·Experimental Hematology·Warren D Shlomchik
Oct 14, 2003·Trends in Immunology·Matthias von Herrath, Dirk Homann
Jun 1, 2005·Trends in Immunology·Tanya N Mayadas, Xavier Cullere
Mar 26, 2004·Journal of Autoimmunity·Julie CabarrocasRoland S Liblau
Oct 18, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Morvarid MoayeriRobert G Hawley
Nov 25, 2003·Lancet·David C WraithPaul-Henri Lambert
Mar 26, 2003·Seminars in Cell & Developmental Biology·Grahame J MckenzieBrian R Champion
Aug 16, 2003·Microbes and Infection·Malin Flodström-Tullberg
Mar 5, 2003·Trends in Immunology·Viktor Müller, Sebastian Bonhoeffer
Nov 17, 2009·Expert Reviews in Molecular Medicine·David M LissauerMark D Kilby
Sep 23, 2008·Cell Death and Differentiation·M DonaldsonS H Jackson
Jun 3, 2005·Nature·John D Rioux, Abul K Abbas
Jun 3, 2005·Nature·Christopher C GoodnowCarola G Vinuesa
Aug 10, 2004·Nature Biotechnology·Gregory A DanielsRichard G Vile
May 18, 2004·Nature Immunology·Antoine PerchelletJoan Goverman
Feb 3, 2005·Nature Immunology·Hans Christian ProbstMaries van den Broek
Nov 21, 2007·Nature Medicine·Pisana Moroni RawsonVincenzo Barnaba
Aug 3, 2004·Nature Reviews. Immunology·Thomas A Wynn
Sep 3, 2004·Nature Reviews. Immunology·Bruno Kyewski, Jens Derbinski
Apr 21, 2005·Nature Reviews. Immunology·Vinay Kumar, Megan E McNerney
Mar 26, 2009·Nature Reviews. Immunology·Christian MünzStephen D Miller
Feb 17, 2010·Nature Reviews. Neurology·Adam E HandelSreeram V Ramagopalan
Jan 9, 2008·Immunology and Cell Biology·Leonard C Harrison
Jan 30, 2008·Immunology and Cell Biology·Ian A Parish, William R Heath
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Martin A KriegelRichard A Flavell
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Maria PapatriantafyllouThilo Oelert
Oct 6, 2010·Journal of Biomolecular Structure & Dynamics·K BhargaviV Uma
Oct 23, 2002·The Journal of Experimental Medicine·Kang LiuRalph M Steinman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.