PMID: 1307034Sep 1, 1992

The energy metabolism of the liver under the action on the body of different durations of hypokinesia

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine
A I GritsiukN K Segal'


Studies of tissue respiration and oxidative phosphorylation of homogenates in the liver of white rats indicated that the 3-day hypokinesia is associated with a decreased rate of endogenic respiration and an increased amythal-resistant respiration. On the 10th day, there occurs a sharp increase of the oxidation rate of the endo- and exogenic substrates and the separation of oxidative phosphorylation takes place. During 30-day immobilization, the homogenate respiratory activity again decreases while on the 70-140th days of an exposure the oxidation rate of endo- and exogenic substrates increases with an increased effect of endogenic succinate on the hepatocyte energy metabolism. The possible mechanism disturbances in the liver of immobilized animals are discussed.

Related Concepts

Energy Metabolism
Oxidative Phosphorylation
Hypokinesia, Experimental
Oxygen Consumption
Physical Restraint

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