The Engagement Between MDSCs and Metastases: Partners in Crime

Frontiers in Oncology
Rosalinda TrovatoFrancesco De Sanctis

Abstract

Tumor metastases represent the major cause of cancer-related mortality, confirming the urgent need to identify key molecular pathways and cell-associated networks during the early phases of the metastatic process to develop new strategies to either prevent or control distal cancer spread. Several data revealed the ability of cancer cells to establish a favorable microenvironment, before their arrival in distant organs, by manipulating the cell composition and function of the new host tissue where cancer cells can survive and outgrow. This predetermined environment is termed "pre-metastatic niche" (pMN). pMN development requires that tumor-derived soluble factors, like cytokines, growth-factors and extracellular vesicles, genetically and epigenetically re-program not only resident cells (i.e., fibroblasts) but also non-resident cells such as bone marrow-derived cells. Indeed, by promoting an "emergency" myelopoiesis, cancer cells switch the steady state production of blood cells toward the generation of pro-tumor circulating myeloid cells defined as myeloid-derived suppressor cells (MDSCs) able to sustain tumor growth and dissemination. MDSCs are a heterogeneous subset of myeloid cells with immunosuppressive properties that sust...Continue Reading

References

Sep 1, 1976·The Journal of Clinical Investigation·J T DanceyC A Finch
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·M OtsujiT Saito
Aug 15, 2000·European Journal of Immunology·B R LúdvíkssonW Strober
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L GorelikR A Flavell
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra MazzoniDavid M Segal
May 8, 2002·The Journal of Experimental Medicine·M F NeurathR S Blumberg
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paulo C RodriguezAugusto C Ochoa
Nov 16, 2004·Biochemical and Biophysical Research Communications·Farid Bouzidi, Jacques Doussiere
Aug 2, 2005·Nature Reviews. Immunology·Vincenzo Bronte, Paola Zanovello
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yulia NefedovaDmitry I Gabrilovich
Sep 28, 2005·The Journal of Experimental Medicine·Paulo C RodriguezAugusto C Ochoa
Nov 22, 2005·Cytokine & Growth Factor Reviews·Christoph BeckerMarkus F Neurath
Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca FallarinoPaolo Puccetti
Oct 7, 2006·Blood·Paulo C RodriguezAugusto C Ochoa
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratima SinhaSuzanne Ostrand-Rosenberg
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingo FrickeDmitry I Gabrilovich
Sep 4, 2007·Nature Reviews. Immunology·Paolo Puccetti, Ursula Grohmann
Dec 8, 2007·Nature·Farbod ShojaeiNapoleone Ferrara
Jul 18, 2008·Cancer Research·Farbod Shojaei, Napoleone Ferrara
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratima SinhaGeetha Srikrishna
Sep 30, 2008·Nature Immunology·Maciej M MarkiewskiJohn D Lambris
Sep 30, 2008·Nature Cell Biology·Sachie HiratsukaYoshiro Maru
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hequan LiXuetao Cao
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer S KoJames H Finke
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Farbod ShojaeiNapoleone Ferrara
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cesar A CorzoDmitry I Gabrilovich
Jun 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liat IzhakNathan Karin
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Nov 26, 2009·Cell·Kandice R LeventalValerie M Weaver
Nov 27, 2009·European Journal of Immunology·Luigi DolcettiVincenzo Bronte
Apr 21, 2010·Cancer Metastasis Reviews·David G DeNardoLisa M Coussens

❮ Previous
Next ❯

Citations

Jul 18, 2020·Frontiers in Immunology·Vladimir Rogovskii
Jan 27, 2021·Annual Review of Pathology·Stefano UgelVincenzo Bronte
Mar 28, 2021·Cancer Communications·Cheng CuiLi Fu
Apr 3, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Slavko MojsilovicJuan F Santibanez
Jun 27, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Jiae KohMyung-Ju Ahn
Jul 10, 2021·Cellular and Molecular Life Sciences : CMLS·Lionel GillotAgnès Noël
Aug 31, 2021·The EMBO Journal·Simone BrabletzMarc P Stemmler

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT03631407
NCT03838367
NCT03161431
NCT02417753
NCT02544880
NCT01697800
NCT03250273
NCT02903914
NCT03837509
NCT03689192

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.