The enhancement effect of estradiol on contextual fear conditioning in female mice

PloS One
Yui K MatsumotoKazuya Tomihara

Abstract

Several studies have reported regulatory effects of estrogens on fear conditioning in female rodents. However, these studies used different doses, durations, and/or administration methods, and reported inconsistent results. To clarify the effect of estrogen on fear conditioning, we investigated the effects of different doses and durations of estradiol administration on freezing behavior during contextual fear conditioning in ovariectomized (OVX) mice. In Experiment 1, OVX ICR mice received a single subcutaneous (s.c.) injection of either oil vehicle (control, 0.1 ml sesame oil) or varied doses (0.5 μg/0.1 ml, 5 μg/0.1 ml, or 50 μg/0.1 ml) of 17β-estradiol-3-benzoate (EB). Fear conditioning was conducted two days post-EB treatment, and the mice were tested for the learned fear response the following day. In Experiment 2, OVX female mice received an s.c. implantation of a Silastic capsule (I.D. 1.98 × 20.0 mm) containing either vehicle or varied doses (0.05 μg/0.1 ml, 0.5 μg/0.1 ml, 5 μg/0.1 ml, 50 μg/0.1 ml) of EB. Two weeks after implantation, fear conditioning was conducted. During the tests conducted 24 h after conditioning, the high dose EB group showed longer freezing times in both experiments, and lower locomotor activity ...Continue Reading

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Citations

Mar 12, 2020·European Journal of Psychotraumatology·Antonia V SeligowskiTeniel S Ramikie
Nov 30, 2019·Frontiers in Behavioral Neuroscience·Anousheh Bakhti-SurooshWendy J Lynch
Jan 12, 2021·American Journal of Physiology. Endocrinology and Metabolism·Naima S DahirTimothy A Gilbertson
May 30, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ryoichi MaenosonoStefan G Tullius
Sep 1, 2021·Journal of Neuroendocrinology·Carly M DrzewieckiJanice M Juraska
Oct 6, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eda BozdemirJames D Lechleiter

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